QuickView for PDIA3;jsessionid=766EB57C156A85E0E104035D6ACEF6EF (gene)

Gene Symbol:

PDIA3 Homo sapiens

Full name:

protein disulfide isomerase family A member 3

Synonyms:

ER60, ERp57, ERp60, ERp61, GRP57, GRP58, HEL-S-269, HEL-S-93n, HsT17083, P58, PI-PLC, protein disulfide-isomerase A3, 58 kDa glucose-regulated protein, 58 kDa microsomal protein, ER protein 57, ER protein 60, disulfide isomerase ER-60, endoplasmic reticulum P58, endoplasmic reticulum resident protein 57, endoplasmic reticulum resident protein 60, epididymis secretory protein Li 269, epididymis secretory sperm binding protein Li 93n, glucose regulated protein, 58kDa, phospholipase C-alpha, protein disulfide isomerase-associated 3

Genomic Location:

Chr 15: 41825882-41852096

Description:

This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that ...

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This gene encodes a protein of the endoplasmic reticulum that interacts with lectin chaperones calreticulin and calnexin to modulate folding of newly synthesized glycoproteins. The protein was once thought to be a phospholipase; however, it has been demonstrated that the protein actually has protein disulfide isomerase activity. It is thought that complexes of lectins and this protein mediate protein folding by promoting formation of disulfide bonds in their glycoprotein substrates. This protein also functions as a molecular chaperone that prevents the formation of protein aggregates.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  TGACCTY_ERR1_Q2 ,  NFY_Q6_01 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AP4_01 ,  GGGCGGR_SP1_Q6 ,  NFY_01 ,  YKACATTT_UNKNOWN ,  MGGAAGTG_GABP_B ,  RNGTGGGC_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  TGACATY_UNKNOWN ,  TGACCTTG_SF1_Q6 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-148

Cytogenetic Map:

15q15.3

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