QuickView for PDLIM3;jsessionid=FAC6F26501ACC752D755F6B36741828C (gene)

Gene Symbol:

PDLIM3 Homo sapiens

Full name:

PDZ and LIM domain 3

Synonyms:

ALP, PDZ and LIM domain protein 3, alpha-actinin-2-associated LIM protein, enigma homolog

Genomic Location:

Chr 4: 186659899-186693650

Description:

The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript v...

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The protein encoded by this gene contains a PDZ domain and a LIM domain, indicating that it may be involved in cytoskeletal assembly. In support of this, the encoded protein has been shown to bind the spectrin-like repeats of alpha-actinin-2 and to colocalize with alpha-actinin-2 at the Z lines of skeletal muscle. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Aberrant alternative splicing of this gene may play a role in myotonic dystrophy.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  RTAAACA_FREAC2_01 ,  CREBP1CJUN_01 ,  CREB_Q4_01 ,  AML_Q6 ,  SRF_Q6 ,  AAGCAAT_MIR137 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  TATAAA_TATA_01 ,  GTGACGY_E4F1_Q6 ,  ATF_01 ,  CAGGTG_E12_Q6 ,  CREB_02 ,  YKACATTT_UNKNOWN ,  E4F1_Q6 ,  HFH8_01 ,  TTGTTT_FOXO4_01 ,  TEF_Q6 ,  TGACGTCA_ATF3_Q6 ,  AACTTT_UNKNOWN ,  CREB_Q2_01 ,  CREB_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-137

Cytogenetic Map:

4q35.1

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