QuickView for PDS5B;jsessionid=377DCE537D9D8C5FDE19251AA59471FB (gene)
- Gene Symbol:
- PDS5B
Homo sapiens - Full name:
- PDS5 cohesin associated factor B
- Synonyms:
- APRIN, AS3, CG008, sister chromatid cohesion protein PDS5 homolog B, androgen induced inhibitor of proliferation, androgen-induced proliferation inhibitor, androgen-induced prostate proliferative shutoff-associated protein AS3, androgen-induced shutoff 3
- Genomic Location:
- Chr 13: 32058624-32250157
- Description:
-
This gene encodes a protein that interacts with the conserved protein complex termed cohesin. The cohesin complex holds together sister chromatids and facilitates accurate chromosome segregation during mitosis and meiosis. This protein is also a negative regulator of cell proliferation and may be a tumor-suppressor gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
13q13.1
GO Molecular Function
nucleic acid binding | ribonucleotide binding | nucleotide binding | carbohydrate derivative binding | ATP binding | anion binding | adenyl nucleotide binding | DNA binding | purine nucleotide binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | heterocyclic compound binding | small molecule binding
GO Biological Process
cell motility | eye development | negative regulation of cellular process | nervous system development | cellular process | localization | autonomic nervous system development | regulation of cellular process | neuroblast migration | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | response to stimulus | chromosome segregation | response to stress | regulation of cell proliferation | cellular nitrogen compound metabolic process | DNA repair | locomotion | system development | nitrogen compound metabolic process | multicellular organism development | cell migration | sister chromatid segregation | cellular response to DNA damage stimulus | cellular response to stress | mitotic sister chromatid cohesion | cell cycle | enteric nervous system development | cell proliferation | cell division | sensory organ development | nuclear chromosome segregation | DNA metabolic process | anatomical structure development | mitotic cell cycle | nuclear division | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | mitotic nuclear division | camera-type eye development | developmental process | organelle organization | sister chromatid cohesion | negative regulation of cell proliferation | heterocycle metabolic process | chromosome organization | cellular metabolic process | mitotic sister chromatid segregation | lens development in camera-type eye | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
chromosome | intracellular membrane-bounded organelle | chromosome, centromeric region | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | chromatin | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | cytosol | intracellular
