QuickView for PDT (gene)

Gene Symbol:

Twist1 Mus musculus

Full name:

twist basic helix-loop-helix transcription factor 1

Synonyms:

M-Twist, Pde, Ska10, Ska<m10Jus>, Twist, bHLHa38, pdt, twist-related protein 1, Pluridigite, charlie chaplin, polydactyly EMS, twist gene homolog 1, twist homolog 1

Genomic Location:

Chr 12: 34642536-34644696

Description:

Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. This gene encodes a bHLH transcription factor that is evolutionarily conserved from invertebrates to humans, and was originally identified in Drosophila as an essential gene involved in early mesoderm development and dorsal-ve...

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Basic helix-loop-helix (bHLH) transcription factors have been implicated in cell lineage determination and differentiation. This gene encodes a bHLH transcription factor that is evolutionarily conserved from invertebrates to humans, and was originally identified in Drosophila as an essential gene involved in early mesoderm development and dorsal-ventral patterning in the embryo. This protein plays a role in cancer by regulating the epithelial-mesenchymal transition (EMT), a process that is critical for metastasis initiation, and promoting tumor progression. Mutations in the human gene are associated with Saethre-Chotzen syndrome (SCS). Mice with heterozygous mutations in this gene exhibit cranofacial and structural defects similar to those seen in human SCS patients.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RSRFC4_01 ,  P300_01 ,  SOX5_01 ,  IRF1_01 ,  EVI1_04 ,  IK1_01 ,  PAX6_01 ,  CDPCR3HD_01 ,  GATA1_03 ,  GATA1_04 ,  FOXD3_01 ,  TST1_01 ,  OCT1_04 ,  TATA_C ,  MEF2_02 ,  MEF2_03 ,  HFH3_01 ,  FREAC7_01 ,  PAX8_B ,  ETS1_B ,  ETS2_B ,  OCT1_B ,  GATA1_05 ,  RSRFC4_Q2 ,  FOXJ2_01 ,  TITF1_Q3 ,  STAT5B_01 ,  POU3F2_01 ,  HIF1_Q5 ,  PITX2_Q2 ,  ATF6_01 ,  NKX62_Q2 ,  STAT4_01 ,  STAT6_02 ,  NERF_Q2 ,  HNF6_Q6 ,  MAF_Q6 ,  PU1_Q6 ,  TEF_Q6 ,  ICSBP_Q6 ,  HNF3ALPHA_Q6 ,  CDX2_Q5 ,  HFH4_01 ,  ELF1_Q6 ,  ETS_Q4 ,  IRF_Q6 ,  HNF3_Q6 ,  SMAD_Q6 ,  TTF1_Q6 ,  OCT_Q6 ,  PIT1_Q6 ,  PAX_Q6 ,  FOX_Q2 ,  CTCTGGA_MIR520A_MIR525 ,  GTGGGTGK_UNKNOWN ,  TCTAGAG_MIR517 ,  CTCAAGA_MIR526B ,  TCTGATA_MIR361 ,  AACATTC_MIR4093P ,  GAGCTGG_MIR337 ,  AGTCTAG_MIR151 ,  TCCAGAG_MIR518C ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  TTGTTT_FOXO4_01 ,  MGGAAGTG_GABP_B ,  TTCNRGNNNNTTC_HSF_Q6 ,  YTATTTTNR_MEF2_02 ,  TGGAAA_NFAT_Q4_01 ,  GATTGGY_NFY_Q6_01 ,  RGAGGAARY_PU1_Q6 ,  CTAWWWATA_RSRFC4_Q2 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-326 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-361 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-151 ,  Predicted Gene Targets for miR-409-3p ,  Predicted Gene Targets for miR-543

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