QuickView for PGA3 (gene)

Gene Symbol:

PGA3 Homo sapiens

Full name:

pepsinogen 3, group I (pepsinogen A)

Synonyms:

pepsin A-3, pepsinogen A3, pepsinogen-3

Genomic Location:

Chr 11: 60727560-60736926

Description:

This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a clust...

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This gene encodes a protein precursor of the digestive enzyme pepsin, a member of the peptidase A1 family of endopeptidases. The encoded precursor is secreted by gastric chief cells and undergoes autocatalytic cleavage in acidic conditions to form the active enzyme, which functions in the digestion of dietary proteins. This gene is found in a cluster of related genes on chromosome 11, each of which encodes one of multiple pepsinogens. Pepsinogen levels in serum may serve as a biomarker for atrophic gastritis and gastric cancer.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus ,  Canis lupus familiaris

External Links:

Entrez Gene

Cytogenetic Map:

11q12.2

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