QuickView for PGD (gene)
- Gene Symbol:
- PGD
Homo sapiens - Full name:
- phosphogluconate dehydrogenase
- Synonyms:
- 6PGD, 6-phosphogluconate dehydrogenase, decarboxylating
- Genomic Location:
- Chr 1: 10381672-10402788
- Description:
-
6-phosphogluconate dehydrogenase is the second dehydrogenase in the pentose phosphate shunt. Deficiency of this enzyme is generally asymptomatic, and the inheritance of this disorder is autosomal dominant. Hemolysis results from combined deficiency of 6-phosphogluconate dehydrogenase and 6-phosphogluconolactonase suggesting a synergism of the two e...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1p36.22
GO Molecular Function
oxidoreductase activity, acting on CH-OH group of donors | NADP binding | cofactor binding | nucleotide binding | coenzyme binding | catalytic activity | organic cyclic compound binding | phosphogluconate dehydrogenase (decarboxylating) activity | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | heterocyclic compound binding | oxidoreductase activity | small molecule binding
GO Biological Process
oxidoreductase activity, acting on CH-OH group of donors | cellular process | nucleotide metabolic process | ribose phosphate metabolic process | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | monocarboxylic acid metabolic process | pentose-phosphate shunt | cellular nitrogen compound metabolic process | pentose biosynthetic process | cofactor metabolic process | nitrogen compound metabolic process | phosphorus metabolic process | organophosphate metabolic process | monosaccharide metabolic process | small molecule metabolic process | cellular carbohydrate metabolic process | nucleobase-containing small molecule metabolic process | carbohydrate biosynthetic process | biosynthetic process | carbohydrate metabolic process | D-gluconate metabolic process | phosphate-containing compound metabolic process | glyceraldehyde-3-phosphate metabolic process | pentose-phosphate shunt, oxidative branch | carboxylic acid metabolic process | cellular aldehyde metabolic process | phosphogluconate dehydrogenase (decarboxylating) activity | metabolic process | oxidation-reduction process | nucleobase-containing compound metabolic process | organic substance metabolic process | glucose 6-phosphate metabolic process | organic acid metabolic process | NADP metabolic process | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor | nicotinamide nucleotide metabolic process | carbohydrate derivative metabolic process | heterocycle metabolic process | pentose metabolic process | cellular metabolic process | oxidoreductase activity
GO Cellular Component
intracellular membrane-bounded organelle | cell | cytoplasm | intracellular organelle | vesicle | extracellular exosome | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | extracellular space | cytosol | intracellular
