QuickView for PGR (gene)

Gene Symbol:

PGR Homo sapiens

Full name:

progesterone receptor

Synonyms:

NR3C3, PR, progesterone receptor, nuclear receptor subfamily 3 group C member 3

Genomic Location:

Chr 11: 100414313-100506465

Description:

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce sever...

View Full Description

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GGGAGGRR_MAZ_Q6 ,  GTCAGGA_MIR378 ,  NKX62_Q2 ,  GGGCGGR_SP1_Q6 ,  SPZ1_01 ,  TAATTA_CHX10_01

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-378

Cytogenetic Map:

11q22.1

search → result