QuickView for PHLPP1 (gene)

Gene Symbol:

PHLPP1 Homo sapiens

Full name:

PH domain and leucine rich repeat protein phosphatase 1

Synonyms:

PHLPP, PLEKHE1, PPM3A, SCOP, PH domain leucine-rich repeat-containing protein phosphatase 1, PH domain-containing family E member 1, SCN circadian oscillatory protein, pleckstrin homology domain containing, family E (with leucine rich repeats) member 1, protein phosphatase, Mg2+/Mn2+ dependent 3A, suprachiasmatic nucleus circadian oscillatory protein

Genomic Location:

Chr 18: 58533714-58798646

Description:

This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering wit...

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This gene encodes a member of the serine/threonine phosphatase family. The encoded protein promotes apoptosis by dephosphorylating and inactivating the serine/threonine kinase Akt, and functions as a tumor suppressor in multiple types of cancer. Increased expression of this gene may also play a role in obesity and type 2 diabetes by interfering with Akt-mediated insulin signaling.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CGTSACG_PAX3_B ,  YTCCCRNNAGGY_UNKNOWN ,  RTAAACA_FREAC2_01 ,  SYATTGTG_UNKNOWN ,  GTGACTT_MIR224 ,  TTTGTAG_MIR520D ,  CAGTGTT_MIR141_MIR200A ,  CREB_Q3 ,  FOXO3_01 ,  GTGACGY_E4F1_Q6 ,  FREAC3_01 ,  ZID_01 ,  GGGCGGR_SP1_Q6 ,  HIF1_Q5 ,  TAATAAT_MIR126 ,  AAAGACA_MIR511 ,  OCT1_02 ,  FREAC2_01 ,  MTF1_Q4 ,  TTGTTT_FOXO4_01 ,  CCAGGGG_MIR331 ,  IRF7_01 ,  WCAANNNYCAG_UNKNOWN ,  PAX3_B ,  RCGCANGCGY_NRF1_Q6 ,  FREAC4_01 ,  FOXO4_02 ,  ACATATC_MIR190 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-190 ,  Predicted Gene Targets for miR-141 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-299 ,  Predicted Gene Targets for miR-331 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-495

miRNA binding sites
(Source: miRecords):

[miR-219] Targeted Genes

Cytogenetic Map:

18q21.33

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