QuickView for PHOX2B (gene)

Gene Symbol:

PHOX2B Homo sapiens

Full name:

paired like homeobox 2b

Synonyms:

NBLST2, NBPhox, PMX2B, paired mesoderm homeobox protein 2B, PHOX2B homeodomain protein, neuroblastoma Phox, neuroblastoma paired-type homeobox protein, paired mesoderm homeobox 2b, paired-like homeobox 2B

Genomic Location:

Chr 4: 41440857-41445744

Description:

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement o...

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The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  FOXO1_02 ,  POU6F1_01 ,  OCT1_07 ,  CMYB_01 ,  PAX4_04 ,  OCT1_05 ,  STAT4_01 ,  PU1_Q6 ,  GATA1_03 ,  SRF_01 ,  TAL1ALPHAE47_01 ,  GATA1_01 ,  OCT1_04 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  NFAT_Q6 ,  SREBP1_02 ,  OCT1_01 ,  HOXA4_Q2 ,  GATA3_01 ,  AP3_Q6 ,  FOXO4_01 ,  POU3F2_01 ,  YTATTTTNR_MEF2_02 ,  NKX3A_01 ,  AAANWWTGC_UNKNOWN ,  CIZ_01 ,  EVI1_04 ,  IPF1_Q4 ,  WGTTNNNNNAAA_UNKNOWN ,  FXR_IR1_Q6 ,  MEIS1BHOXA9_01 ,  STAT6_01 ,  TAAYNRNNTCC_UNKNOWN ,  HNF1_C ,  IRF1_Q6 ,  NKX22_01 ,  OCT1_Q5_01 ,  E2F1_Q4 ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  YAATNRNNNYNATT_UNKNOWN ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  AR_Q6 ,  CDPCR3HD_01 ,  OCT1_Q6 ,  TAL1BETAE47_01 ,  PAX4_02 ,  GGGYGTGNY_UNKNOWN ,  GGATTA_PITX2_Q2 ,  RP58_01 ,  CEBP_01 ,  FREAC3_01 ,  RFX1_02 ,  CDX2_Q5 ,  STAT5B_01 ,  CTCAGGG_MIR125B_MIR125A ,  CACCAGC_MIR138 ,  CAGCTTT_MIR320 ,  YY1_01 ,  LHX3_01 ,  TST1_01 ,  ATF3_Q6 ,  STAT5A_03 ,  CEBPB_02 ,  ATGTTTC_MIR494 ,  LMO2COM_02 ,  OCT1_03 ,  S8_01 ,  NKX61_01 ,  RAAGNYNNCTTY_UNKNOWN ,  AGGTGCA_MIR500 ,  PAX6_01 ,  TGCCAAR_NF1_Q6 ,  HFH4_01 ,  GCCNNNWTAAR_UNKNOWN ,  POU1F1_Q6 ,  TGTTTGY_HNF3_Q6 ,  GATA1_02 ,  OCT1_06 ,  YCATTAA_UNKNOWN ,  GATA2_01 ,  AR_Q2 ,  RNGTGGGC_UNKNOWN ,  HMGIY_Q6 ,  NCX_01 ,  MEIS1AHOXA9_01 ,  OCT1_02 ,  CEBP_Q3 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  CHOP_01 ,  AAAYRNCTG_UNKNOWN ,  CART1_01 ,  AFP1_Q6 ,  MSX1_01 ,  STAT5A_04 ,  WTTGKCTG_UNKNOWN ,  TEF_Q6 ,  CTGYNNCTYTAA_UNKNOWN ,  TTCYNRGAA_STAT5B_01 ,  TAL1BETAITF2_01 ,  TCCATTKW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  STAT5A_01 ,  NFKB_Q6_01 ,  CDC5_01 ,  BRN2_01 ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  PAX2_02 ,  HNF1_Q6 ,  COREBINDINGFACTOR_Q6 ,  CTGRYYYNATT_UNKNOWN ,  HNF6_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-146 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-500 ,  Predicted Gene Targets for miR-543

Cytogenetic Map:

4p13

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