QuickView for PIAS1 (gene)

Gene Symbol:

PIAS1 Homo sapiens

Full name:

protein inhibitor of activated STAT 1

Synonyms:

DDXBP1, GBP, GU/RH-II, ZMIZ3, E3 SUMO-protein ligase PIAS1, AR interacting protein, DEAD/H (Asp-Glu-Ala-Asp/His) box binding protein 1, DEAD/H box-binding protein 1, RNA helicase II-binding protein, gu-binding protein, protein inhibitor of activated STAT protein 1, zinc finger, MIZ-type containing 3

Genomic Location:

Chr 15: 66133626-66267467

Description:

This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and n...

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This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  FREAC7_01 ,  SMTTTTGT_UNKNOWN ,  TTANTCA_UNKNOWN ,  GATA3_01 ,  LXR_DR4_Q3 ,  ATGTACA_MIR493 ,  SREBP1_Q6 ,  IRF1_Q6 ,  MYB_Q5_01 ,  GCCATNTTG_YY1_Q6 ,  TATAAA_TATA_01 ,  CAGGTA_AREB6_01 ,  CAGGTG_E12_Q6 ,  SP1_Q4_01 ,  AP2_Q6_01 ,  RRAGTTGT_UNKNOWN ,  ACTGCCT_MIR34B ,  OCT1_03 ,  CCCNNGGGAR_OLF1_01 ,  POU1F1_Q6 ,  SP1_Q6 ,  TGTTTGY_HNF3_Q6 ,  NRF2_Q4 ,  TTGTTT_FOXO4_01 ,  IK2_01 ,  IK1_01 ,  E2F1_Q3 ,  TGACAGNY_MEIS1_01 ,  RCGCANGCGY_NRF1_Q6 ,  SP1_Q6_01 ,  SRY_02 ,  AACTTT_UNKNOWN ,  E2F_Q3 ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  DR4_Q2 ,  E2F_Q3_01 ,  GGGTGGRR_PAX4_03

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-375 ,  Predicted Gene Targets for miR-493-5p

Cytogenetic Map:

15q23

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