QuickView for PICALM;jsessionid=814CDBEFFE05C727B0E5729D232093E4 (gene)

Gene Symbol:

PICALM Homo sapiens

Full name:

phosphatidylinositol binding clathrin assembly protein

Synonyms:

CALM, CLTH, LAP, phosphatidylinositol-binding clathrin assembly protein, clathrin assembly lymphoid myeloid leukemia protein

Genomic Location:

Chr 11: 85346133-85457756

Description:

This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in ...

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This gene encodes a clathrin assembly protein, which recruits clathrin and adaptor protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. The protein may be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage. The protein is involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. A chromosomal translocation t(10;11)(p13;q14) leading to the fusion of this gene and the MLLT10 gene is found in acute lymphoblastic leukemia, acute myeloid leukemia and malignant lymphomas. The polymorphisms of this gene are associated with the risk of Alzheimer disease. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  CRGAARNNNNCGA_UNKNOWN ,  PR_Q2 ,  NFMUE1_Q6 ,  TTTGCAG_MIR518A2 ,  TAL1ALPHAE47_01 ,  USF_Q6 ,  TCANNTGAY_SREBP1_01 ,  ZIC1_01 ,  RYTTCCTG_ETS2_B ,  ARNT_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  VDR_Q3 ,  AP3_Q6 ,  MYCMAX_03 ,  CACGTG_MYC_Q2 ,  SRF_Q6 ,  ZF5_01 ,  CATTGTYY_SOX9_B1 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  PEA3_Q6 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  ARNT_02 ,  TTF1_Q6 ,  AAGCAAT_MIR137 ,  MYCMAX_B ,  AML1_01 ,  HNF4_DR1_Q3 ,  OSF2_Q6 ,  TGAYRTCA_ATF3_Q6 ,  AGCATTA_MIR155 ,  SOX9_B1 ,  SREBP1_01 ,  ACATTCC_MIR1_MIR206 ,  RREB1_01 ,  CAGGTG_E12_Q6 ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AP4_Q6 ,  AP2_Q6_01 ,  HNF4_Q6 ,  GGGCGGR_SP1_Q6 ,  MGGAAGTG_GABP_B ,  SPZ1_01 ,  USF_01 ,  KCCGNSWTTT_UNKNOWN ,  RACCACAR_AML_Q6 ,  AHR_01 ,  RNGTGGGC_UNKNOWN ,  AATGTGA_MIR23A_MIR23B ,  AML1_Q6 ,  MTF1_Q4 ,  USF_Q6_01 ,  MYOGENIN_Q6 ,  CTGCAGY_UNKNOWN ,  TGCTTTG_MIR330 ,  TAL1BETAITF2_01 ,  SRF_Q5_01 ,  AAGCACT_MIR520F ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  CACBINDINGPROTEIN_Q6 ,  USF2_Q6 ,  P300_01 ,  AACTTT_UNKNOWN ,  PAX4_03 ,  TGACATY_UNKNOWN ,  CTAGGAA_MIR384 ,  ER_Q6 ,  USF_02 ,  ACCTGTTG_UNKNOWN ,  CCAWWNAAGG_SRF_Q4 ,  COREBINDINGFACTOR_Q6 ,  HNF4_01_B ,  PAX4_01 ,  GGGTGGRR_PAX4_03 ,  LBP1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-155 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-384

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Cytogenetic Map:

11q14.2

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