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QuickView for PITX1 (gene)


Gene Symbol:
PITX1 Homo sapiens Homo sapiens
Full name:
paired like homeodomain 1
Synonyms:
BFT, CCF, LBNBG, POTX, PTX1, pituitary homeobox 1, hindlimb expressed homeobox protein backfoot, homeobox protein PITX1, paired-like homeodomain transcription factor 1, pituitary homeo box 1, pituitary otx-related factor
Genomic Location:
Chr 5: 134391323-134397863
Description:
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family are involved in organ development and left-right asymmetry. This protein acts as a transcriptional regulator involved in basal and hormone-regulated activity of prolactin.
Orthologs:
Mus musculus Rattus norvegicus Macaca mulatta Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 5
5q31.1


Transcripts Names
NM_002653



GO Molecular Function

sequence-specific DNA binding | transcription factor activity, transcription factor binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | transcription factor activity, RNA polymerase II transcription factor binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | transcriptional activator activity, RNA polymerase II transcription factor binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | transcription factor binding | RNA polymerase II transcription factor binding | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | brain development | limb development | transcription factor activity, transcription factor binding | positive regulation of macromolecule biosynthetic process | muscle tissue development | negative regulation of cellular process | RNA polymerase II transcription factor activity, sequence-specific DNA binding | negative regulation of RNA biosynthetic process | embryonic appendage morphogenesis | cell differentiation | nervous system development | positive regulation of cellular biosynthetic process | cellular process | limb morphogenesis | negative regulation of nucleic acid-templated transcription | positive regulation of nitrogen compound metabolic process | transcription factor activity, RNA polymerase II transcription factor binding | diencephalon development | negative regulation of cellular metabolic process | tissue development | muscle structure development | skeletal muscle organ development | hindlimb morphogenesis | regulation of cellular process | regulation of metabolic process | pituitary gland development | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | head development | embryonic limb morphogenesis | skeletal muscle tissue development | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cartilage development | cellular biosynthetic process | embryo development | regulation of nucleic acid-templated transcription | system development | nitrogen compound metabolic process | multicellular organism development | regulation of gene expression | myoblast fate commitment | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | regulation of transcription by RNA polymerase II | biosynthetic process | aromatic compound biosynthetic process | endocrine system development | striated muscle tissue development | regulation of cellular metabolic process | regulation of RNA metabolic process | embryonic hindlimb morphogenesis | embryonic morphogenesis | transcriptional activator activity, RNA polymerase II transcription factor binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | gland development | anatomical structure development | metabolic process | cell fate commitment | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | nucleobase-containing compound metabolic process | organic substance metabolic process | connective tissue development | negative regulation of biosynthetic process | negative regulation of gene expression | animal organ development | forebrain development | gene expression | transcription, DNA-templated | branchiomeric skeletal muscle development | regulation of transcription, DNA-templated | myoblast differentiation | anatomical structure morphogenesis | cellular macromolecule biosynthetic process | developmental process | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | central nervous system development | positive regulation of metabolic process | skeletal system development | cellular metabolic process | muscle organ development | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process

GO Cellular Component

intracellular membrane-bounded organelle | cell | nuclear lumen | transcription factor complex | nucleolus | cytoplasm | intracellular organelle | protein-containing complex | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular