QuickView for PKP2;jsessionid=E2B844CE02CF383D22275B6C2F51A334 (gene)
- Gene Symbol:
- PKP2
Homo sapiens - Full name:
- plakophilin 2
- Synonyms:
- ARVD9, plakophilin-2
- Genomic Location:
- Chr 12: 32834947-32941047
- Description:
-
This gene encodes a member of the arm-repeat (armadillo) and plakophilin gene families. Plakophilin proteins contain numerous armadillo repeats, localize to cell desmosomes and nuclei, and participate in linking cadherins to intermediate filaments in the cytoskeleton. This gene product may regulate the signaling activity of beta-catenin. Two altern...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus , Danio rerio
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
12p11.21
GO Molecular Function
structural molecule activity | kinase binding | channel regulator activity | cadherin binding | protein binding involved in heterotypic cell-cell adhesion | protein kinase binding | enzyme binding | protein-containing complex binding | sodium channel regulator activity | cell-cell adhesion mediator activity | molecular function regulator | ion channel binding | protein kinase C binding | cell adhesion molecule binding | protein binding | alpha-catenin binding | protein-containing complex scaffold activity | cell adhesion mediator activity | intermediate filament binding | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
GO Biological Process
regulation of muscle system process | ventricular cardiac muscle tissue morphogenesis | heart process | actin filament-based process | protein localization to cell periphery | muscle tissue development | regulation of localization | intermediate filament organization | regulation of sodium ion transport | bundle of His cell-Purkinje myocyte adhesion involved in cell communication | heterotypic cell-cell adhesion | negative regulation of cellular process | cell differentiation | regulation of ventricular cardiac muscle cell action potential | cellular process | channel regulator activity | localization | heart morphogenesis | protein binding involved in heterotypic cell-cell adhesion | macromolecule localization | tissue development | regulation of cell differentiation | actin filament-based movement | muscle structure development | cell junction assembly | regulation of cellular process | sodium channel regulator activity | cell-cell adhesion mediator activity | heart contraction | ventricular cardiac muscle cell action potential | epithelium development | cellular component organization | actin-mediated cell contraction | cornification | muscle contraction | muscle organ morphogenesis | regulation of blood circulation | regulation of cardiac muscle cell contraction | cardiac muscle tissue development | muscle tissue morphogenesis | programmed cell death | supramolecular fiber organization | regulation of heart rate | cellular localization | cardiac ventricle morphogenesis | blood circulation | cellular component assembly | cell-cell signaling | molecular function regulator | cell communication by electrical coupling | regulation of membrane potential | system development | adherens junction organization | multicellular organism development | cardiac muscle cell-cardiac muscle cell adhesion | regulation of muscle contraction | protein localization to plasma membrane | intermediate filament bundle assembly | protein localization to membrane | desmosome assembly | animal organ morphogenesis | regulation of cellular component movement | cardiac muscle cell action potential involved in contraction | bundle of His cell to Purkinje myocyte communication | epidermal cell differentiation | cell communication by electrical coupling involved in cardiac conduction | epidermis development | cell-cell signaling involved in cardiac conduction | keratinization | skin development | regulation of heart contraction | keratinocyte differentiation | regulation of striated muscle contraction | striated muscle tissue development | cardiac muscle tissue morphogenesis | cell communication | cardiac muscle cell contraction | regulation of cardiac muscle contraction | regulation of cardiac muscle cell action potential | desmosome organization | heart development | positive regulation of transport | striated muscle contraction | cardiac ventricle development | regulation of heart rate by cardiac conduction | tissue morphogenesis | ventricular cardiac muscle tissue development | anatomical structure development | cellular component maintenance | maintenance of animal organ identity | cell-cell junction assembly | cellular protein localization | cell communication involved in cardiac conduction | intermediate filament-based process | cell adhesion | cell death | animal organ development | positive regulation of ion transport | positive regulation of sodium ion transport | cytoskeleton organization | cell-cell adhesion | regulation of action potential | cell adhesion mediator activity | action potential | signaling | protein localization | anatomical structure morphogenesis | cellular macromolecule localization | adherens junction maintenance | regulation of developmental process | regulation of ion transport | developmental process | cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication | organelle organization | regulation of transport | intermediate filament cytoskeleton organization | cardiac muscle cell action potential | epithelial cell differentiation | cardiac chamber development | regulation of actin filament-based process | cardiac muscle contraction | circulatory system development | negative regulation of cell differentiation | homotypic cell-cell adhesion | muscle organ development | muscle system process | cardiac conduction | multicellular organismal process | cell-cell junction organization
GO Cellular Component
intermediate filament | supramolecular fiber | intercalated disc | integral component of membrane | intracellular membrane-bounded organelle | adherens junction | cell | nuclear lumen | intrinsic component of membrane | cytoplasm | intracellular organelle | intermediate filament cytoskeleton | cell-cell adherens junction | cell-cell junction | cell-cell contact zone | cornified envelope | protein-containing complex | nucleoplasm | plasma membrane | ribonucleoprotein complex | membrane-bounded organelle | nucleus | organelle | messenger ribonucleoprotein complex | cell periphery | membrane-enclosed lumen | desmosome | cytoskeleton | intracellular | cell junction | membrane | supramolecular complex
