QuickView for PLA2G1B (gene)

Gene Symbol:

PLA2G1B Homo sapiens

Full name:

phospholipase A2 group IB

Synonyms:

PLA2, PLA2A, PPLA2, phospholipase A2, phosphatidylcholine 2-acylhydrolase 1B, phospholipase A2, group IB (pancreas)

Genomic Location:

Chr 12: 119244297-119249975

Description:

This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream ...

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This gene encodes a secreted member of the phospholipase A2 (PLA2) class of enzymes, which is produced by the pancreatic acinar cells. The encoded calcium-dependent enzyme catalyzes the hydrolysis of the sn-2 position of membrane glycerophospholipids to release arachidonic acid (AA) and lysophospholipids. AA is subsequently converted by downstream metabolic enzymes to several bioactive lipophilic compounds (eicosanoids), including prostaglandins (PGs) and leukotrienes (LTs). The enzyme may be involved in several physiological processes including cell contraction, cell proliferation and pathological response.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Bos taurus ,  Canis lupus familiaris ,  Danio rerio ,  Pan troglodytes ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF3ALPHA_Q6 ,  GATA3_01 ,  GATA_Q6 ,  GATA_C ,  GATAAGR_GATA_C ,  DBP_Q6 ,  LMO2COM_02 ,  TGTTTGY_HNF3_Q6 ,  GATA1_02

Cytogenetic Map:

12q24.31

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