QuickView for PLA2G2D (gene)
- Gene Symbol:
- PLA2G2D
Homo sapiens - Full name:
- phospholipase A2 group IID
- Synonyms:
- PLA2IID, SPLASH, sPLA2-IID, sPLA2S, group IID secretory phospholipase A2, GIID sPLA2, phosphatidylcholine 2-acylhydrolase 2D, secretory phospholipase A2s, secretory-type PLA, stroma-associated homolog
- Genomic Location:
- Chr 1: 20311019-20318595
- Description:
-
This gene encodes a secreted member of the phospholipase A2 family, and is found in a cluster of related family members on chromosome 1. Phospholipase A2 family members hydrolyze the sn-2 fatty acid ester bond of glycerophospholipids to produce lysophospholipids and free fatty acid. This gene may be involved in inflammation and immune response, and...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Pan troglodytes , Canis lupus familiaris
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1p36.12
GO Molecular Function
proteoglycan binding | calcium-dependent phospholipase A2 activity | cation binding | phospholipase activity | lipid binding | carboxylic ester hydrolase activity | hydrolase activity | carbohydrate derivative binding | phospholipid binding | catalytic activity | anion binding | phospholipase A2 activity | hydrolase activity, acting on ester bonds | ion binding | heparin binding | lipase activity | heparan sulfate proteoglycan binding | phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) | protein binding | glycosaminoglycan binding | calcium ion binding | metal ion binding | phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
GO Biological Process
negative regulation of leukocyte activation | long-chain fatty acid transport | negative regulation of immune system process | CD4-positive, alpha-beta T cell differentiation | CD4-positive, alpha-beta T cell activation | phosphatidylglycerol acyl-chain remodeling | lipid transport | phosphatidylglycerol metabolic process | phosphatidylinositol metabolic process | establishment of localization | regulation of immune system process | negative regulation of cellular process | negative regulation of leukocyte cell-cell adhesion | cell differentiation | defense response | phosphatidylserine metabolic process | phospholipid metabolic process | cellular process | secretion | organic substance catabolic process | lymphocyte differentiation | phosphatidylinositol acyl-chain remodeling | monocarboxylic acid transport | phosphatidylcholine acyl-chain remodeling | localization | anion transport | immune system development | macromolecule localization | negative regulation of T cell proliferation | regulation of cellular process | leukocyte activation | catabolic process | negative regulation of mononuclear cell proliferation | cellular lipid metabolic process | T cell activation | response to stimulus | acid secretion | negative regulation of cell adhesion | response to stress | negative regulation of lymphocyte activation | regulation of cell proliferation | hemopoiesis | regulation of cell adhesion | cellular biosynthetic process | leukocyte differentiation | system development | nitrogen compound metabolic process | multicellular organism development | phosphatidic acid metabolic process | phosphorus metabolic process | lipid metabolic process | arachidonic acid secretion | regulation of T cell activation | fatty acid transport | phosphatidylethanolamine acyl-chain remodeling | organic substance transport | organophosphate metabolic process | regulation of lymphocyte activation | phospholipid biosynthetic process | negative regulation of T cell activation | alpha-beta T cell differentiation | organic acid transport | biosynthetic process | organic anion transport | lipid biosynthetic process | phosphate-containing compound metabolic process | negative regulation of cell-cell adhesion | negative regulation of cell activation | inflammatory response | glycerolipid metabolic process | lymphocyte activation | T cell differentiation | glycerophospholipid biosynthetic process | anatomical structure development | metabolic process | lipid localization | negative regulation of leukocyte proliferation | lipid catabolic process | organic substance metabolic process | animal organ development | regulation of cell activation | phosphatidylcholine metabolic process | regulatory T cell differentiation | alpha-beta T cell activation | cell activation | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation | regulation of T cell proliferation | carboxylic acid transport | glycerophospholipid metabolic process | developmental process | negative regulation of cell proliferation | regulation of cell-cell adhesion | cellular modified amino acid metabolic process | ion transport | negative regulation of lymphocyte proliferation | immune system process | phosphatidic acid biosynthetic process | cellular metabolic process | hematopoietic or lymphoid organ development | phosphatidylserine acyl-chain remodeling | multicellular organismal process
