QuickView for PLA2G4A (gene)

Gene Symbol:

PLA2G4A Homo sapiens

Full name:

phospholipase A2 group IVA

Synonyms:

PLA2G4, cPLA2, cPLA2-alpha, cytosolic phospholipase A2, calcium-dependent phospholipid-binding protein, lysophospholipase, phosphatidylcholine 2-acylhydrolase, phospholipase A2, group IVA (cytosolic, calcium-dependent)

Genomic Location:

Chr 1: 185064655-185224736

Description:

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory...

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This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CEBPA_01 ,  HNF1_01 ,  MYC_Q2 ,  CACGTG_MYC_Q2 ,  GAGACTG_MIR452 ,  CEBP_Q2_01 ,  HNF1_C ,  CTTTGA_LEF1_Q2 ,  CEBP_Q2 ,  CEBPDELTA_Q6 ,  CEBPB_01 ,  LEF1_Q2 ,  USF_C ,  CEBPB_02 ,  NMYC_01 ,  CEBP_Q3 ,  CEBP_C ,  RGAGGAARY_PU1_Q6 ,  USF2_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-543

Cytogenetic Map:

1q31.1

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