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QuickView for PLA2G4A (gene)

Gene Symbol:
PLA2G4A Homo sapiens Homo sapiens
Full name:
phospholipase A2 group IVA
PLA2G4, cPLA2, cPLA2-alpha, cytosolic phospholipase A2, calcium-dependent phospholipid-binding protein, lysophospholipase, phosphatidylcholine 2-acylhydrolase, phospholipase A2, group IVA (cytosolic, calcium-dependent)
Genomic Location:
Chr 1: 185064655-185224736
This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory...
Mus musculus Rattus norvegicus Macaca mulatta Danio rerio Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 1

GO Molecular Function

calcium-dependent phospholipase A2 activity | cation binding | phospholipase activity | phosphatidylcholine 1-acylhydrolase activity | lipid binding | carboxylic ester hydrolase activity | hydrolase activity | phospholipid binding | catalytic activity | anion binding | phospholipase A2 activity | hydrolase activity, acting on ester bonds | ion binding | lipase activity | phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine) | lysophospholipase activity | calcium ion binding | calcium-dependent phospholipid binding | metal ion binding | phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)

GO Biological Process

long-chain fatty acid transport | phosphatidylglycerol acyl-chain remodeling | lipid transport | phosphatidylglycerol metabolic process | phosphatidylinositol metabolic process | establishment of localization | phosphatidylserine metabolic process | organophosphate catabolic process | response to antibiotic | phospholipid metabolic process | cellular process | secretion | organic substance catabolic process | phosphatidylinositol acyl-chain remodeling | monocarboxylic acid transport | phosphatidylcholine acyl-chain remodeling | localization | anion transport | macromolecule localization | regulation of cellular process | catabolic process | icosanoid biosynthetic process | cellular lipid metabolic process | response to stimulus | acid secretion | monocarboxylic acid metabolic process | glycerophospholipid catabolic process | regulation of cell proliferation | cellular biosynthetic process | platelet activating factor biosynthetic process | nitrogen compound metabolic process | cellular response to antibiotic | phosphatidic acid metabolic process | cardiolipin acyl-chain remodeling | phosphorus metabolic process | lipid metabolic process | arachidonic acid secretion | fatty acid transport | phosphatidylethanolamine acyl-chain remodeling | organic substance transport | organophosphate metabolic process | phospholipid biosynthetic process | cardiolipin metabolic process | small molecule metabolic process | phospholipid catabolic process | organic acid transport | biosynthetic process | organic anion transport | lipid biosynthetic process | phosphate-containing compound metabolic process | platelet activating factor metabolic process | cellular lipid catabolic process | glycerolipid metabolic process | long-chain fatty acid metabolic process | drug metabolic process | carboxylic acid metabolic process | glycerophospholipid biosynthetic process | metabolic process | lipid localization | lipid catabolic process | organic substance metabolic process | phosphatidylcholine metabolic process | fatty acid metabolic process | icosanoid metabolic process | organic acid metabolic process | carboxylic acid transport | glycerophospholipid metabolic process | cellular modified amino acid metabolic process | ion transport | phosphatidic acid biosynthetic process | cellular metabolic process | arachidonic acid metabolic process | phosphatidylserine acyl-chain remodeling

GO Cellular Component

organelle inner membrane | intracellular membrane-bounded organelle | mitochondrial inner membrane | organelle membrane | cytoplasmic vesicle | cell | cytoplasm | intracellular organelle | endoplasmic reticulum | Golgi apparatus | nuclear outer membrane-endoplasmic reticulum membrane network | endomembrane system | endoplasmic reticulum membrane | vesicle | lipid droplet | mitochondrion | membrane-bounded organelle | nucleus | organelle | mitochondrial envelope | mitochondrial membrane | cytosol | intracellular vesicle | intracellular | membrane