QuickView for PLCB1;jsessionid=176BDEE376F12E03E598CF656B88C902 (gene)

Gene Symbol:

PLCB1 Homo sapiens

Full name:

phospholipase C beta 1

Synonyms:

EIEE12, PI-PLC, PLC-154, PLC-I, PLC-beta-1, PLC154, PLCB1A, PLCB1B, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1, 1-phosphatidyl-D-myo-inositol-4,5-bisphosphate, inositoltrisphosphohydrolase, monophosphatidylinositol phosphodiesterase, phosphoinositidase C, phospholipase C, beta 1 (phosphoinositide-specific), phospholipase C-I, triphosphoinositide phosphodiesterase

Genomic Location:

Chr 20: 8061296-8813547

Description:

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q ...

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The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  OCT1_07 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  TTTGCAC_MIR19A_MIR19B ,  TTTGCAG_MIR518A2 ,  TAL1ALPHAE47_01 ,  AAGCCAT_MIR135A_MIR135B ,  E4BP4_01 ,  CTTTGCA_MIR527 ,  CTATGCA_MIR153 ,  TGTGTGA_MIR377 ,  CEBP_Q2_01 ,  TACTTGA_MIR26A_MIR26B ,  TTGCACT_MIR130A_MIR301_MIR130B ,  AAGCAAT_MIR137 ,  ATCTTGC_MIR31 ,  CEBP_Q2 ,  CEBPB_01 ,  TAL1BETAE47_01 ,  CAGGTA_AREB6_01 ,  RREB1_01 ,  P53_02 ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  HNF3B_01 ,  GGGCGGR_SP1_Q6 ,  NKX61_01 ,  E47_01 ,  TGCCAAR_NF1_Q6 ,  SOX5_01 ,  AGGGCCA_MIR328 ,  GTGCCTT_MIR506 ,  HLF_01 ,  EN1_01 ,  TTGTTT_FOXO4_01 ,  TGCTTTG_MIR330 ,  TAL1BETAITF2_01 ,  TGCACTT_MIR519C_MIR519B_MIR519A ,  ZF5_B ,  AACTTT_UNKNOWN ,  PAX4_03 ,  YNGTTNNNATT_UNKNOWN ,  ATGAAGG_MIR205 ,  AGGAAGC_MIR5163P ,  CACTTTG_MIR520G_MIR520H

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-125 ,  Predicted Gene Targets for miR-130 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-19 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-205 ,  Predicted Gene Targets for miR-26 ,  Predicted Gene Targets for miR-328 ,  Predicted Gene Targets for miR-330 ,  Predicted Gene Targets for miR-34 ,  Predicted Gene Targets for miR-377 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-137

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Cytogenetic Map:

20p12.3

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