QuickView for PLCD3;jsessionid=4F3E745D2C96C6B4BDABA79C73C35308 (gene)

Gene Symbol:

PLCD3 Homo sapiens

Full name:

phospholipase C delta 3

Synonyms:

PLC-delta-3, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3, 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3, PLC delta3, phosphoinositide phospholipase C-delta-3

Genomic Location:

Chr 17: 40544534-40565417

Description:

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing ...

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This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  C. elegans ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CREBP1CJUN_01 ,  CREB_Q4_01 ,  HEN1_01 ,  CREB_Q3 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  GTGACGY_E4F1_Q6 ,  CAGGTG_E12_Q6 ,  ATF3_Q6 ,  RNGTGGGC_UNKNOWN ,  TGACGTCA_ATF3_Q6 ,  TCF1P_Q6 ,  CREB_01

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Cytogenetic Map:

17q21.31

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