QuickView for PLEKHA1 (gene)

Gene Symbol:

PLEKHA1 Homo sapiens

Full name:

pleckstrin homology domain containing A1

Synonyms:

TAPP1, pleckstrin homology domain-containing family A member 1, pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1, tandem PH domain-containing protein 1

Genomic Location:

Chr 10: 124124210-124181856

Description:

This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related ...

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This gene encodes a pleckstrin homology domain-containing adapter protein. The encoded protein is localized to the plasma membrane where it specifically binds phosphatidylinositol 3,4-bisphosphate. This protein may be involved in the formation of signaling complexes in the plasma membrane. Polymorphisms in this gene are associated with age-related macular degeneration. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 5.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ATAAGCT_MIR21 ,  RYTTCCTG_ETS2_B ,  CATTGTYY_SOX9_B1 ,  STAT6_01 ,  GTGCAAT_MIR25_MIR32_MIR92_MIR363_MIR367 ,  ATAGGAA_MIR202 ,  TGAYRTCA_ATF3_Q6 ,  TATAAA_TATA_01 ,  PXR_Q2 ,  TGCGCANK_UNKNOWN ,  YGCANTGCR_UNKNOWN ,  ATF3_Q6 ,  STAT5A_03 ,  ACTGCCT_MIR34B ,  ACTAYRNNNCCCR_UNKNOWN ,  CTTTAAR_UNKNOWN ,  NRF1_Q6 ,  YGCGYRCGC_UNKNOWN ,  ATF1_Q6 ,  GATA1_05 ,  RCGCANGCGY_NRF1_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  DR4_Q2 ,  PAX4_01 ,  SF1_Q6

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-15 ,  Predicted Gene Targets for miR-186 ,  Predicted Gene Targets for miR-21 ,  Predicted Gene Targets for miR-25 ,  Predicted Gene Targets for miR-34b ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-29

Cytogenetic Map:

10q26.13

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