QuickView for PLK1 (gene)
- Gene Symbol:
- PLK1
Homo sapiens - Full name:
- polo like kinase 1
- Synonyms:
- PLK, STPK13, serine/threonine-protein kinase PLK1, PLK-1, cell cycle regulated protein kinase, polo (Drosophia)-like kinase, serine/threonine-protein kinase 13
- Genomic Location:
- Chr 16: 23597702-23609189
- Description:
-
The Ser/Thr protein kinase encoded by this gene belongs to the CDC5/Polo subfamily. It is highly expressed during mitosis and elevated levels are found in many different types of cancer. Depletion of this protein in cancer cells dramatically inhibited cell proliferation and induced apoptosis; hence, it is a target for cancer therapy.
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
16p12.2
GO Molecular Function
kinase binding | cation binding | protein kinase binding | magnesium ion binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | anaphase-promoting complex binding | carbohydrate derivative binding | protein serine/threonine kinase activity | catalytic activity | ATP binding | cytoskeletal protein binding | anion binding | adenyl nucleotide binding | purine nucleotide binding | identical protein binding | ion binding | organic cyclic compound binding | purine ribonucleoside triphosphate binding | protein binding | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | microtubule binding | purine ribonucleotide binding | tubulin binding | adenyl ribonucleotide binding | drug binding | kinase activity | metal ion binding | heterocyclic compound binding | small molecule binding
GO Biological Process
mitotic cytokinesis | negative regulation of phosphorylation | nucleus organization | regulation of cell cycle process | regulation of cellular localization | intracellular signal transduction | proteolysis | regulation of localization | microtubule bundle formation | regulation of programmed cell death | peptidyl-amino acid modification | positive regulation of peptidyl-threonine phosphorylation | establishment of localization | negative regulation of cellular process | negative regulation of kinase activity | negative regulation of RNA biosynthetic process | microtubule cytoskeleton organization | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | positive regulation of protein catabolic process | negative regulation of protein phosphorylation | positive regulation of phosphate metabolic process | regulation of organelle organization | membrane organization | microtubule-based process | regulation of chromosome segregation | cellular process | organic substance catabolic process | localization | proteolysis involved in cellular protein catabolic process | regulation of ubiquitin-protein transferase activity | cytoskeleton-dependent cytokinesis | regulation of mitotic nuclear division | multicellular organismal reproductive process | negative regulation of nucleic acid-templated transcription | regulation of chromosome separation | macromolecule localization | negative regulation of chromosome segregation | negative regulation of apoptotic process | endomembrane system organization | microtubule organizing center organization | regulation of proteolysis | membrane docking | regulation of cell cycle | positive regulation of catalytic activity | membrane disassembly | positive regulation of nitrogen compound metabolic process | regulation of mitotic spindle organization | negative regulation of cellular metabolic process | regulation of binding | gamete generation | negative regulation of mitotic metaphase/anaphase transition | spindle checkpoint | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | catabolic process | organelle localization | positive regulation of ubiquitin protein ligase activity | positive regulation of cellular protein metabolic process | regulation of G2/M transition of mitotic cell cycle | cellular component organization | regulation of cell division | positive regulation of cellular protein catabolic process | response to stimulus | female gamete generation | regulation of cellular protein localization | female meiosis chromosome segregation | regulation of mitotic cell cycle phase transition | chromosome segregation | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | response to stress | negative regulation of protein kinase activity | positive regulation of cellular protein localization | regulation of protein ubiquitination | anaphase-promoting complex-dependent catabolic process | synaptonemal complex disassembly | protein localization to nucleus | regulation of cell cycle phase transition | mitotic nuclear envelope disassembly | protein serine/threonine kinase activity | protein destabilization | positive regulation of proteolysis involved in cellular protein catabolic process | reproduction | cellular protein catabolic process | cellular localization | positive regulation of proteolysis | proteasomal protein catabolic process | nuclear envelope organization | negative regulation of metabolic process | cellular component assembly | protein modification process | macromolecule modification | regulation of mitotic spindle assembly | meiotic chromosome segregation | ciliary basal body-plasma membrane docking | regulation of nucleic acid-templated transcription | organelle assembly | regulation of cell cycle G2/M phase transition | regulation of cyclin-dependent protein serine/threonine kinase activity | nitrogen compound metabolic process | reproductive process | negative regulation of mitotic cell cycle phase transition | regulation of protein stability | negative regulation of phosphate metabolic process | negative regulation of catalytic activity | negative regulation of cell cycle G2/M phase transition | sister chromatid segregation | phosphorus metabolic process | cellular response to DNA damage stimulus | regulation of catalytic activity | regulation of protein serine/threonine kinase activity | regulation of phosphorylation | signal transduction in response to DNA damage | regulation of gene expression | cellular response to stress | cell cycle | protein catabolic process | negative regulation of cyclin-dependent protein serine/threonine kinase activity | cell projection assembly | regulation of spindle assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of protein localization to nucleus | regulation of mitotic sister chromatid separation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of protein serine/threonine kinase activity | regulation of transcription by RNA polymerase II | protein localization to organelle | negative regulation of mitotic nuclear division | cell proliferation | positive regulation of protein localization to nucleus | cell division | regulation of cellular protein metabolic process | synaptonemal complex organization | positive regulation of proteasomal protein catabolic process | G2/M transition of mitotic cell cycle | cytokinesis | phosphorylation | signal transduction involved in cell cycle checkpoint | mitotic spindle assembly checkpoint | mitotic cell cycle phase transition | protein phosphorylation | phosphate-containing compound metabolic process | nuclear chromosome segregation | protein localization to chromatin | nuclear envelope disassembly | cell communication | regulation of cellular metabolic process | regulation of protein kinase activity | negative regulation of mitotic sister chromatid segregation | regulation of cytokinesis | regulation of protein metabolic process | cell cycle G2/M phase transition | negative regulation of mitotic sister chromatid separation | regulation of protein phosphorylation | regulation of RNA metabolic process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of mitotic cell cycle | regulation of microtubule-based process | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | multicellular organism reproduction | negative regulation of cyclin-dependent protein kinase activity | homologous chromosome segregation | protein metabolic process | positive regulation of protein modification process | protein ubiquitination | centrosome cycle | protein localization to nuclear envelope | regulation of kinase activity | cellular macromolecule catabolic process | regulation of sister chromatid segregation | mitotic cell cycle | nuclear division | cell projection organization | metabolic process | positive regulation of ubiquitin-dependent protein catabolic process | regulation of protein catabolic process | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of mitotic cell cycle | cellular protein localization | signal transduction involved in G2 DNA damage checkpoint | protein kinase activity | organic substance metabolic process | negative regulation of biosynthetic process | negative regulation of gene expression | cilium assembly | negative regulation of cellular protein metabolic process | protein modification by small protein conjugation or removal | regulation of phosphate metabolic process | cytoskeleton organization | regulation of chromosome organization | mitotic nuclear division | establishment of protein localization | meiosis I | ubiquitin-dependent protein catabolic process | negative regulation of cell cycle | cilium organization | negative regulation of protein metabolic process | organonitrogen compound catabolic process | regulation of mitotic sister chromatid segregation | meiotic cell cycle | negative regulation of chromosome organization | negative regulation of molecular function | signaling | regulation of transcription, DNA-templated | regulation of protein binding | protein localization | positive regulation of phosphorylation | cellular protein metabolic process | cellular macromolecule localization | signal transduction involved in DNA damage checkpoint | kinase activity | organelle organization | peptidyl-serine phosphorylation | sister chromatid cohesion | cellular protein modification process | negative regulation of transcription by RNA polymerase II | regulation of mitotic metaphase/anaphase transition | cell cycle phase transition | positive regulation of ubiquitin-protein transferase activity | positive regulation of metabolic process | chromosome organization | mitotic cell cycle checkpoint | cellular metabolic process | negative regulation of cell cycle process | regulation of protein localization | regulation of cell death | modification-dependent protein catabolic process | regulation of organelle assembly | DNA damage checkpoint | cell cycle checkpoint | negative regulation of cell death | regulation of ubiquitin-dependent protein catabolic process | mitotic sister chromatid segregation | sexual reproduction | positive regulation of protein ubiquitination | regulation of microtubule cytoskeleton organization | regulation of cellular component organization | regulation of cytoskeleton organization | protein localization to chromosome | signal transduction | female meiotic nuclear division | macromolecule metabolic process | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
condensed nuclear chromosome | supramolecular fiber | chromosome | centriole | intracellular membrane-bounded organelle | condensed nuclear chromosome kinetochore | microtubule organizing center | chromosome, centromeric region | condensed chromosome outer kinetochore | condensed chromosome, centromeric region | cell | nuclear lumen | kinetochore | synaptonemal complex | microtubule | cytoplasm | spindle | centriolar satellite | intracellular organelle | centrosome | protein-containing complex | nucleoplasm | midbody | chromatin | condensed nuclear chromosome, centromeric region | nuclear chromosome | condensed chromosome kinetochore | microtubule cytoskeleton | spindle pole | spindle microtubule | spindle midzone | membrane-bounded organelle | condensed nuclear chromosome outer kinetochore | nucleus | organelle | membrane-enclosed lumen | cytosol | cytoskeleton | intracellular | supramolecular complex | condensed chromosome
