QuickView for PLN (gene)

Gene Symbol:

PLN Homo sapiens

Full name:

phospholamban

Synonyms:

CMD1P, CMH18, PLB, cardiac phospholamban

Genomic Location:

Chr 6: 118976165-118988280

Description:

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation ...

View Full Description

The protein encoded by this gene is found as a pentamer and is a major substrate for the cAMP-dependent protein kinase in cardiac muscle. The encoded protein is an inhibitor of cardiac muscle sarcoplasmic reticulum Ca(2+)-ATPase in the unphosphorylated state, but inhibition is relieved upon phosphorylation of the protein. The subsequent activation of the Ca(2+) pump leads to enhanced muscle relaxation rates, thereby contributing to the inotropic response elicited in heart by beta-agonists. The encoded protein is a key regulator of cardiac diastolic function. Mutations in this gene are a cause of inherited human dilated cardiomyopathy with refractory congestive heart failure, and also familial hypertrophic cardiomyopathy.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  SRF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  NFY_C ,  GATAAGR_GATA_C ,  TGAYRTCA_ATF3_Q6 ,  TTGTTT_FOXO4_01 ,  TEF_Q6 ,  SRF_Q5_01 ,  TCCATTKW_UNKNOWN ,  CAGCTG_AP4_Q5 ,  CCAWWNAAGG_SRF_Q4 ,  SRF_C

View More

View Less

Cytogenetic Map:

6q22.31

search → result