QuickView for PMCAs (biogroup)

Description:: ATP2B4 (also known as PMCA4) belongs to the IIB subfamily of P-type ATPases, whose members are plasma membrane Ca2+ ATPases (PMCAs) that catalyse the hydrolysis of ATP coupled with the transport of calcium. PMCAs play important roles for the regulation of bone homeostasis in both mice and humans by modulating Ca(2+) signalling in osteoclasts.ATP2B4 is is expressed at high levels in numerous tissues/cell types, including the brain, the heart, and the spermatozoa. The C-terminal of ATP2B4 interacts with the PDZ domains of a number of partner proteins, including neuronal nitric-oxide synthase (nNOS). The interaction between ATP2B4 and neuronal nitric-oxide synthase regulates cardiac contractility through modulation of a compartmentalised cyclic nucleotide microdomain. ATP2B4 is highly concentrated in the spermatozoon head and is involved in the fertilisation process. It also has a role in colon cancer tumourigenesis.
Taxonomy/Path:: InterPro : P-type ATPase, subfamily IIIA / Plasma membrane calcium-transporting ATPase 4

1 feature

Symbol	EntrezGene ID
ATP2B4	493