QuickView for PML (gene)

Gene Symbol:

PML Homo sapiens

Full name:

promyelocytic leukemia

Synonyms:

MYL, PP8675, RNF71, TRIM19, protein PML, PML/RARA fusion, RING finger protein 71, probable transcription factor PML, promyelocytic leukemia protein, promyelocytic leukemia, inducer of, tripartite motif protein TRIM19, tripartite motif-containing protein 19

Genomic Location:

Chr 15: 72074067-72127213

Description:

The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle r...

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The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

ETS_Q4 ,  P53_DECAMER_Q2 ,  P53_02 ,  CTCAAGA_MIR526B ,  MGGAAGTG_GABP_B ,  RGAGGAARY_PU1_Q6 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  P300_01 ,  ETS1_B

Cytogenetic Map:

15q24.1

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