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QuickView for PMPCB;jsessionid=D9F81CF33120DB47B20390D96FC253EE (gene)


Gene Symbol:
PMPCB Homo sapiens Homo sapiens
Full name:
peptidase, mitochondrial processing beta subunit
Synonyms:
Beta-MPP, MPP11, MPPB, MPPP52, P-52, mitochondrial-processing peptidase subunit beta, mitochondrial processing peptidase beta subunit, peptidase (mitochondrial processing) beta
Genomic Location:
Chr 7: 102725109-102742369
Description:
This gene is a member of the peptidase M16 family and encodes a protein with a zinc-binding motif. This protein is located in the mitochondrial matrix and catalyzes the cleavage of the leader peptides of precursor proteins newly imported into the mitochondria, though it only functions as part of a heterodimeric complex.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Macaca mulatta Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Danio rerio Bos taurus
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 7
7q22.1





GO Molecular Function

metallopeptidase activity | metalloendopeptidase activity | hydrolase activity | catalytic activity | endopeptidase activity | peptidase activity

GO Biological Process

metallopeptidase activity | purine ribonucleotide metabolic process | proteolysis | protein localization to mitochondrion | establishment of localization | protein processing | generation of precursor metabolites and energy | aerobic respiration | intracellular transport | cellular process | localization | protein transport | metalloendopeptidase activity | nucleotide metabolic process | metal ion transport | ATP synthesis coupled electron transport | cellular respiration | establishment of protein localization to mitochondrion | ribose phosphate metabolic process | macromolecule localization | mitochondrial calcium ion transmembrane transport | nucleoside triphosphate metabolic process | ribonucleotide metabolic process | establishment of localization in cell | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | cellular component organization | purine nucleotide metabolic process | intracellular protein transport | electron transport chain | cellular localization | divalent metal ion transport | cellular nitrogen compound metabolic process | mitochondrion organization | nitrogen compound metabolic process | calcium ion transmembrane transport | phosphorus metabolic process | ion transmembrane transport | organic substance transport | organophosphate metabolic process | mitochondrial transport | small molecule metabolic process | peptide transport | protein localization to organelle | nucleobase-containing small molecule metabolic process | phosphorylation | protein maturation | phosphate-containing compound metabolic process | protein processing involved in protein targeting to mitochondrion | mitochondrial ATP synthesis coupled electron transport | drug metabolic process | cation transmembrane transport | protein metabolic process | mitochondrial protein processing | establishment of protein localization to organelle | metabolic process | oxidation-reduction process | cellular protein localization | amide transport | calcium ion transport | oxidative phosphorylation | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | inorganic cation transmembrane transport | establishment of protein localization | transmembrane transport | endopeptidase activity | protein localization | cellular protein metabolic process | cation transport | cellular macromolecule localization | protein targeting to mitochondrion | energy derivation by oxidation of organic compounds | organelle organization | mitochondrial electron transport, ubiquinol to cytochrome c | carbohydrate derivative metabolic process | heterocycle metabolic process | protein targeting | ion transport | cellular metabolic process | peptidase activity | ATP metabolic process | macromolecule metabolic process | respiratory electron transport chain

GO Cellular Component

mitochondrial matrix | organelle inner membrane | intracellular membrane-bounded organelle | catalytic complex | mitochondrial inner membrane | organelle membrane | cell | oxidoreductase complex | cytoplasm | intracellular organelle | respiratory chain complex III | protein-containing complex | mitochondrial respiratory chain | respiratory chain | cytochrome complex | mitochondrion | membrane-bounded organelle | organelle | mitochondrial envelope | membrane-enclosed lumen | mitochondrial membrane | intracellular | mitochondrial processing peptidase complex | mitochondrial respiratory chain complex III | membrane