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QuickView for POLR3A (gene)


Gene Symbol:
POLR3A Homo sapiens Homo sapiens
Full name:
RNA polymerase III subunit A
Synonyms:
ADDH, HLD7, RPC1, RPC155, hRPC155, DNA-directed RNA polymerase III subunit RPC1, DNA-directed RNA polymerase III largest subunit, DNA-directed RNA polymerase III subunit A, RNA polymerase III 155 kDa subunit, RNA polymerase III subunit C1, RNA polymerase III subunit C160, RNA polymerase III subunit RPC155-D, polymerase (RNA) III (DNA directed) polypeptide A, 155kDa, polymerase (RNA) III subunit A
Genomic Location:
Chr 10: 79405900-79459265
Description:
The protein encoded by this gene is the catalytic component of RNA polymerase III, which synthesizes small RNAs. The encoded protein also acts as a sensor to detect foreign DNA and trigger an innate immune response.
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Saccharomyces cerevisiae Schizosaccharomyces pombe Gallus gallus Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 10
10q22.3


Transcripts Names
NM_007055
Protein Names
Q8TCW5
O14802
Q8IW34



GO Molecular Function

RNA polymerase III activity | cation binding | nucleic acid binding | 5'-3' RNA polymerase activity | nucleotidyltransferase activity | catalytic activity | chromatin binding | DNA binding | ion binding | organic cyclic compound binding | transferase activity, transferring phosphorus-containing groups | transferase activity | DNA-directed 5'-3' RNA polymerase activity | metal ion binding | heterocyclic compound binding

GO Biological Process

RNA metabolic process | response to virus | defense response to other organism | defense response | RNA polymerase III activity | cellular process | regulation of interferon-beta production | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | regulation of type I interferon production | response to stimulus | response to stress | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | cellular biosynthetic process | response to external biotic stimulus | nitrogen compound metabolic process | defense response to virus | biosynthetic process | aromatic compound biosynthetic process | metabolic process | transcription by RNA polymerase III | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | gene expression | transcription, DNA-templated | positive regulation of cytokine production | regulation of cytokine production | cellular macromolecule biosynthetic process | response to biotic stimulus | innate immune response | heterocycle metabolic process | DNA-directed 5'-3' RNA polymerase activity | immune system process | cellular metabolic process | positive regulation of type I interferon production | response to other organism | macromolecule metabolic process | positive regulation of interferon-beta production

GO Cellular Component

RNA polymerase III complex | intracellular membrane-bounded organelle | catalytic complex | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | cytosol | intracellular | membrane