QuickView for POU2F2 (gene)
- Gene Symbol:
- POU2F2
Homo sapiens - Full name:
- POU class 2 homeobox 2
- Synonyms:
- OCT2, OTF2, Oct-2, POU domain, class 2, transcription factor 2, OTF-2, homeobox protein, lymphoid-restricted immunoglobulin octamer-binding protein NF-A2, octamer-binding protein 2, octamer-binding transcription factor 2
- Genomic Location:
- Chr 19: 47284490-47328470
- Description:
-
The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene.
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Canis lupus familiaris , Danio rerio , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- miRNA binding sites
(Source: TargetScan):
- Cytogenetic Map:
-
19q13.2
GO Molecular Function
sequence-specific DNA binding | transcription regulatory region DNA binding | RNA polymerase II transcription factor activity, sequence-specific DNA binding | proximal promoter sequence-specific DNA binding | nucleic acid binding | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | protein domain specific binding | RNA polymerase II regulatory region DNA binding | DNA binding | sequence-specific double-stranded DNA binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | RNA polymerase II proximal promoter sequence-specific DNA binding | double-stranded DNA binding | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | RNA polymerase II regulatory region sequence-specific DNA binding | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | transcription by RNA polymerase II | adaptive immune response | positive regulation of macromolecule biosynthetic process | snRNA metabolic process | establishment of localization | RNA polymerase II transcription factor activity, sequence-specific DNA binding | cell differentiation | B cell differentiation | positive regulation of cellular biosynthetic process | cellular process | secretion | lymphocyte differentiation | localization | cell maturation | protein transport | immune system development | macromolecule localization | positive regulation of nitrogen compound metabolic process | snRNA transcription | regulation of cellular process | leukocyte activation | regulation of metabolic process | immunoglobulin secretion | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | response to stimulus | mature B cell differentiation | cellular nitrogen compound biosynthetic process | snRNA transcription by RNA polymerase II | secretion by cell | cellular nitrogen compound metabolic process | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding | positive regulation of RNA biosynthetic process | hemopoiesis | cellular biosynthetic process | regulation of nucleic acid-templated transcription | leukocyte differentiation | adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains | system development | nitrogen compound metabolic process | multicellular organism development | leukocyte mediated immunity | ncRNA transcription | regulation of gene expression | organic substance transport | positive regulation of cellular metabolic process | regulation of nitrogen compound metabolic process | peptide transport | regulation of transcription by RNA polymerase II | B cell activation | biosynthetic process | aromatic compound biosynthetic process | peptide secretion | regulation of cellular metabolic process | humoral immune response | regulation of RNA metabolic process | lymphocyte activation | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding | DNA-binding transcription factor activity | anatomical structure development | metabolic process | immunoglobulin production involved in immunoglobulin mediated immune response | immunoglobulin production | regulation of RNA biosynthetic process | developmental maturation | amide transport | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | animal organ development | gene expression | establishment of protein localization | transcription, DNA-templated | cell activation | regulation of transcription, DNA-templated | cell development | protein localization | cellular macromolecule biosynthetic process | B cell mediated immunity | developmental process | positive regulation of transcription, DNA-templated | ncRNA metabolic process | positive regulation of nucleic acid-templated transcription | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | immunoglobulin secretion involved in immune response | immunoglobulin mediated immune response | immune system process | cellular metabolic process | hematopoietic or lymphoid organ development | protein secretion | positive regulation of gene expression | macromolecule metabolic process | multicellular organismal process
GO Cellular Component
intracellular membrane-bounded organelle | cell | nuclear lumen | cytoplasm | intracellular organelle | nucleoplasm | membrane-bounded organelle | nucleus | organelle | membrane-enclosed lumen | intracellular
