QuickView for PPARGC1 (gene)

Gene Symbol:

Ppargc1a Mus musculus

Full name:

peroxisome proliferative activated receptor, gamma, coactivator 1 alpha

Synonyms:

A830037N07Rik, Gm11133, PGC-1, PPARGC-1-alpha, Pgc-1alpha, Pgc1, Pgco1, Ppargc1, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PPAR-gamma coactivator 1-alpha

Genomic Location:

Chr 5: 51848892-51945100

Description:

This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced ...

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This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants.

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Orthologs:

Homo sapiens ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

AAANWWTGC_UNKNOWN ,  MYOD_01 ,  AACTTT_UNKNOWN ,  ATF_01 ,  CREB_01 ,  CREBP1CJUN_01 ,  IRF1_01 ,  EVI1_02 ,  EVI1_03 ,  EVI1_04 ,  EVI1_05 ,  CREB_02 ,  USF_02 ,  ACTAYRNNNCCCR_UNKNOWN ,  HNF3B_01 ,  HNF4_01 ,  OCT1_02 ,  COUP_01 ,  CREB_Q2 ,  CREB_Q4 ,  CREBP1_Q2 ,  MYOD_Q6 ,  MEF2_02 ,  MEF2_03 ,  MEF2_04 ,  PPARA_01 ,  CHOP_01 ,  GFI1_01 ,  ISRE_01 ,  LMO2COM_02 ,  TCF11MAFG_01 ,  HFH8_01 ,  WHN_B ,  ATF_B ,  AMEF2_Q6 ,  HNF4_01_B ,  AREB6_01 ,  FOXJ2_02 ,  NKX61_01 ,  TITF1_Q3 ,  AR_Q2 ,  GATA6_01 ,  POU6F1_01 ,  TBP_01 ,  CDC5_01 ,  STAT4_01 ,  STAT5A_04 ,  PPARG_01 ,  ATF3_Q6 ,  CTTTAAR_UNKNOWN ,  CEBPGAMMA_Q6 ,  DBP_Q6 ,  FOXM1_01 ,  GATA4_Q3 ,  HNF4ALPHA_Q6 ,  HOXA4_Q2 ,  PTF1BETA_Q6 ,  TCF4_Q5 ,  E4F1_Q6 ,  ICSBP_Q6 ,  GCCNNNWTAAR_UNKNOWN ,  CDX2_Q5 ,  IRF1_Q6 ,  DR1_Q3 ,  PPAR_DR1_Q2 ,  HNF4_DR1_Q3 ,  COUP_DR1_Q6 ,  STAT_Q6 ,  GATA_Q6 ,  HNF1_Q6 ,  CREB_Q3 ,  CREB_Q2_01 ,  MEF2_Q6_01 ,  AR_Q6 ,  TGGTGCT_MIR29A_MIR29B_MIR29C ,  TGCACTG_MIR148A_MIR152_MIR148B ,  AAAGGGA_MIR204_MIR211 ,  AATGTGA_MIR23A_MIR23B ,  ATGTAGC_MIR221_MIR222 ,  ACACTGG_MIR199A_MIR199B ,  ATGTTAA_MIR302C ,  CTATGCA_MIR153 ,  TATTATA_MIR374 ,  TGTATGA_MIR4853P ,  ATGTTTC_MIR494 ,  AATGGAG_MIR136 ,  CCTGTGA_MIR513 ,  CAGCTTT_MIR320 ,  AAGCACA_MIR218 ,  ATACCTC_MIR202 ,  RAAGNYNNCTTY_UNKNOWN ,  AAGCAAT_MIR137 ,  TTTGTAG_MIR520D ,  AAAGACA_MIR511 ,  GACAATC_MIR219 ,  ACTGTAG_MIR139 ,  TTTTGAG_MIR373 ,  CACCAGC_MIR138 ,  ATCATGA_MIR433 ,  CAGCCTC_MIR4855P ,  TAATAAT_MIR126 ,  TAATGTG_MIR323 ,  CAATGCA_MIR33 ,  TGGNNNNNNKCCAR_UNKNOWN ,  YTAAYNGCT_UNKNOWN ,  TGANTCA_AP1_C ,  TGACGTCA_ATF3_Q6 ,  TGAYRTCA_ATF3_Q6 ,  CAGGTG_E12_Q6 ,  GTGACGY_E4F1_Q6 ,  TGACCTY_ERR1_Q2 ,  TTGTTT_FOXO4_01 ,  RTAAACA_FREAC2_01 ,  GATAAGR_GATA_C ,  TGATTTRY_GFI1_01 ,  AAAYWAACM_HFH4_01 ,  STTTCRNTTT_IRF_Q6 ,  CTTTGA_LEF1_Q2 ,  CTTTGT_LEF1_Q2 ,  YTATTTTNR_MEF2_02 ,  TGACAGNY_MEIS1_01 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  TGGAAA_NFAT_Q4_01 ,  CTAWWWATA_RSRFC4_Q2 ,  TAAWWATAG_RSRFC4_Q2 ,  TCANNTGAY_SREBP1_01 ,  TATAAA_TATA_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-136 ,  Predicted Gene Targets for miR-138 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-148 ,  Predicted Gene Targets for miR-150 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-194 ,  Predicted Gene Targets for miR-199 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-214 ,  Predicted Gene Targets for miR-217 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-219 ,  Predicted Gene Targets for miR-22 ,  Predicted Gene Targets for miR-221 ,  Predicted Gene Targets for miR-23 ,  Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-320 ,  Predicted Gene Targets for miR-323 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-369-3p ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-494 ,  Predicted Gene Targets for miR-539 ,  Predicted Gene Targets for miR-7 ,  Predicted Gene Targets for miR-137 ,  Predicted Gene Targets for miR-29 ,  Predicted Gene Targets for miR-374 ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-485-3p ,  Predicted Gene Targets for miR-495 ,  Predicted Gene Targets for miR-496 ,  Predicted Gene Targets for miR-543

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