QuickView for PPIE;jsessionid=7089798E46C3414798AE8785BA3F2A55 (gene)
- Gene Symbol:
- PPIE
Homo sapiens - Full name:
- peptidylprolyl isomerase E
- Synonyms:
- CYP-33, CYP33, peptidyl-prolyl cis-trans isomerase E, PPIase E, cyclophilin-33, peptidylprolyl isomerase E (cyclophilin E), rotamase E
- Genomic Location:
- Chr 1: 39977117-40002173
- Description:
-
The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein contains a highly conserved cyclophilin (CYP) domain as well as an RNA-binding domain. It was show...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Macaca mulatta , Gallus gallus , Pan troglodytes , Danio rerio , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p34.2
GO Molecular Function
peptide binding | cyclosporin A binding | isomerase activity | nucleic acid binding | poly(A) binding | mRNA binding | unfolded protein binding | catalytic activity | single-stranded RNA binding | amide binding | peptidyl-prolyl cis-trans isomerase activity | organic cyclic compound binding | poly-purine tract binding | protein binding | drug binding | heterocyclic compound binding | RNA binding
GO Biological Process
RNA metabolic process | exocytosis | RNA processing | neutrophil activation | peptidyl-amino acid modification | establishment of localization | positive regulation of viral life cycle | cellular process | secretion | leukocyte degranulation | localization | peptidyl-proline modification | regulation of cellular process | leukocyte activation | regulation of metabolic process | positive regulation of viral genome replication | organic cyclic compound metabolic process | cellular aromatic compound metabolic process | response to stimulus | RNA splicing | neutrophil degranulation | response to stress | RNA splicing, via transesterification reactions | leukocyte activation involved in immune response | secretion by cell | cellular nitrogen compound metabolic process | protein modification process | mRNA metabolic process | macromolecule modification | DNA repair | regulation of nucleic acid-templated transcription | nitrogen compound metabolic process | positive regulation of viral process | cellular response to DNA damage stimulus | leukocyte mediated immunity | regulation of gene expression | cellular response to stress | regulation of nitrogen compound metabolic process | vesicle-mediated transport | peptidyl-prolyl cis-trans isomerase activity | regulated exocytosis | regulation of cellular metabolic process | cell activation involved in immune response | myeloid cell activation involved in immune response | neutrophil activation involved in immune response | regulation of RNA metabolic process | regulation of viral process | protein metabolic process | DNA metabolic process | metabolic process | nucleotide-excision repair | regulation of RNA biosynthetic process | immune response | nucleobase-containing compound metabolic process | organic substance metabolic process | protein folding | gene expression | cell activation | transcription-coupled nucleotide-excision repair | regulation of transcription, DNA-templated | cellular protein metabolic process | cellular protein modification process | neutrophil mediated immunity | heterocycle metabolic process | protein peptidyl-prolyl isomerization | immune system process | cellular metabolic process | regulation of viral genome replication | mRNA processing | regulation of viral life cycle | mRNA splicing, via spliceosome | macromolecule metabolic process
GO Cellular Component
secretory granule | intracellular membrane-bounded organelle | catalytic complex | catalytic step 2 spliceosome | cytoplasmic vesicle | cell | nuclear lumen | cytoplasmic vesicle lumen | Prp19 complex | cytoplasm | intracellular organelle | nuclear body | ficolin-1-rich granule lumen | protein-containing complex | secretory vesicle | endomembrane system | nucleoplasm | U2-type spliceosomal complex | nuclear speck | ribonucleoprotein complex | vesicle | spliceosomal complex | extracellular region | membrane-bounded organelle | nucleus | organelle | U2-type catalytic step 2 spliceosome | membrane-enclosed lumen | secretory granule lumen | cytosol | intracellular vesicle | intracellular | vesicle lumen
