QuickView for PPM1A;jsessionid=C11836744F93C496E3B1544EBB6B62FA (gene)

Gene Symbol:

PPM1A Homo sapiens

Full name:

protein phosphatase, Mg2+/Mn2+ dependent 1A

Synonyms:

PP2C-ALPHA, PP2CA, PP2Calpha, protein phosphatase 1A, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform

Genomic Location:

Chr 14: 59782223-59829826

Description:

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p...

View Full Description

The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Danio rerio ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CREBP1CJUN_01 ,  CREB_Q4_01 ,  MYCMAX_03 ,  YTATTTTNR_MEF2_02 ,  CACGTG_MYC_Q2 ,  GCANCTGNY_MYOD_Q6 ,  MAX_01 ,  CREB_Q4 ,  GGGAGGRR_MAZ_Q6 ,  TGAYRTCA_ATF3_Q6 ,  ATF_B ,  CREBP1_Q2 ,  MYCMAX_02 ,  CEBPDELTA_Q6 ,  TGTATGA_MIR4853P ,  CEBPB_01 ,  ATCATGA_MIR433 ,  GTGACGY_E4F1_Q6 ,  YYCATTCAWW_UNKNOWN ,  NFY_Q6_01 ,  ATF_01 ,  CAGCTTT_MIR320 ,  GR_Q6 ,  CREB_02 ,  ATF3_Q6 ,  GGGCGGR_SP1_Q6 ,  GTATGAT_MIR154_MIR487 ,  NFY_01 ,  USF_01 ,  PAX8_B ,  USF_Q6_01 ,  YGCGYRCGC_UNKNOWN ,  CCTGCTG_MIR214 ,  TGACGTCA_ATF3_Q6 ,  RCGCANGCGY_NRF1_Q6 ,  CAGCTG_AP4_Q5 ,  ZF5_B ,  AACTTT_UNKNOWN ,  TGACATY_UNKNOWN ,  TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497 ,  USF_02 ,  CREB_Q2_01 ,  CREB_01 ,  LMO2COM_01 ,  TCF11_01 ,  LBP1_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-320

Cytogenetic Map:

14q23.1

search → result