QuickView for PPP1R16A;jsessionid=4511C26A2BED7709371B59D80B97F935 (gene)

Gene Symbol:

PPP1R16A Homo sapiens

Full name:

protein phosphatase 1 regulatory subunit 16A

Synonyms:

MYPT3, protein phosphatase 1 regulatory subunit 16A, myosin phosphatase-targeting subunit 3, protein phosphatase 1, regulatory (inhibitor) subunit 16A

Genomic Location:

Chr 8: 145692917-145698312

Description:

Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein enc...

View Full Description

Myosin light chain kinase and phosphatase (MLCP) complexes control the phosphorylation states of regulatory myosin light chains, which is crucial for muscle and intracellular movement. MLCPs typically contain a catalytic protein phosphatase 1 (PP1c) subunit, a myosin phosphatase targeting (MYPT) subunit, and another smaller subunit. The protein encoded by this gene represents an MYPT subunit, which is responsible for directing PP1c to its intended targets. However, while other MYPTs result in PP1c activation after becoming phosphorylated, the encoded protein is phosphorylated by protein kinase A and then inhibits the catalytic activity of PP1c.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Macaca mulatta ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATA1_03 ,  ROAZ_01 ,  PAX4_02 ,  LFA1_Q6 ,  S8_01 ,  NCX_01 ,  MTF1_Q4 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  GATA1_05 ,  ER_Q6_01 ,  GTTNYYNNGGTNA_UNKNOWN

View More

View Less

Cytogenetic Map:

8q24.3

search → result