QuickView for PR72 (gene)

Gene Symbol:

PPP2R3A Homo sapiens

Full name:

protein phosphatase 2 regulatory subunit B''alpha

Synonyms:

PPP2R3, PR130, PR72, serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit alpha, PP2A subunit B isoforms B72/B130, PP2A, subunit B, R3 isoform, PR130/B''alpha1 subunit, PR72/B''alpha2 subuit, protein phosphatase 2 (formerly 2A), regulatory subunit B'' (PR 72), alpha isoform and (PR 130), beta isoform, protein phosphatase 2, regulatory subunit B'', alpha, serine/threonine-protein phosphatase 2A 72/130 kDa regulatory subunit B

Genomic Location:

Chr 3: 137167257-137349423

Description:

This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalyt...

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This gene encodes one of the regulatory subunits of the protein phosphatase 2. Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B'' family. The B'' family has been further divided into subfamilies. The product of this gene belongs to the alpha subfamily of regulatory subunit B''. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Canis lupus familiaris ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

NFAT_Q4_01 ,  TGGAAA_NFAT_Q4_01 ,  YTCCCRNNAGGY_UNKNOWN ,  PR_Q2 ,  AACWWCAANK_UNKNOWN ,  SP1_01 ,  RTAAACA_FREAC2_01 ,  OCT1_05 ,  CACTGCC_MIR34A_MIR34C_MIR449 ,  OCT1_B ,  OCT1_04 ,  RSRFC4_01 ,  OCT1_01 ,  GATA_Q6 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  YTATTTTNR_MEF2_02 ,  SRF_Q6 ,  GCANCTGNY_MYOD_Q6 ,  HFH1_01 ,  IPF1_Q4 ,  XBP1_01 ,  WGTTNNNNNAAA_UNKNOWN ,  TAAYNRNNTCC_UNKNOWN ,  GATAAGR_GATA_C ,  GR_Q6_01 ,  COUP_01 ,  OCT1_Q5_01 ,  OCT_C ,  GATA1_04 ,  TGACCTY_ERR1_Q2 ,  HEB_Q6 ,  TAAWWATAG_RSRFC4_Q2 ,  MEF2_02 ,  STAT_Q6 ,  OCT1_Q6 ,  STAT5A_03 ,  SRF_Q4 ,  LMO2COM_02 ,  CTTTAAR_UNKNOWN ,  TGTTTGY_HNF3_Q6 ,  RACCACAR_AML_Q6 ,  STAT_01 ,  HMGIY_Q6 ,  TTGTTT_FOXO4_01 ,  AAAYRNCTG_UNKNOWN ,  MEF2_03 ,  TTCYNRGAA_STAT5B_01 ,  SRF_Q5_01 ,  AAGCACT_MIR520F ,  RYAAAKNNNNNNTTGW_UNKNOWN ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  FREAC4_01 ,  SRF_C ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-143 ,  Predicted Gene Targets for miR-28 ,  Predicted Gene Targets for miR-33 ,  Predicted Gene Targets for miR-34

Cytogenetic Map:

3q22.2-q22.3

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