QuickView for PREX2;jsessionid=97AA562A1245C47BADAF8A32B6FF46D3 (gene)

Gene Symbol:

PREX2 Homo sapiens

Full name:

phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

Synonyms:

DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 2 protein, DEP domain-containing protein 2, PtdIns(3,4,5)-dependent Rac exchanger 2, protein phosphatase 1, regulatory subunit 129

Genomic Location:

Chr 8: 69027157-69306451

Description:

The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain...

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The protein encoded by this gene belongs to the phosphatidylinositol 3,4,5-trisphosphate (PIP3)-dependent Rac exchanger (PREX) family, which are Dbl-type guanine-nucleotide exchange factors for Rac family small G proteins. Structural domains of this protein include the catalytic diffuse B-cell lymphoma homology and pleckstrin homology (DHPH) domain, two disheveled, EGL-10, and pleckstrin homology (DEP) domains, two PDZ domains, and a C-terminal inositol polyphosphate-4 phosphatase (IP4P) domain that is found in one of the isoforms. This protein facilitates the exchange of GDP for GTP on Rac1, allowing the GTP-bound Rac1 to activate downstream effectors. Studies also show that the pleckstrin homology domain of this protein interacts with the phosphatase and tensin homolog (PTEN) gene product to inhibit PTEN phosphatase activity, thus activating the phosphoinositide-3 kinase (PI3K) signaling pathway. Conversely, the PTEN gene product has also been shown to inhibit the GEF activity of this protein. This gene plays a role in insulin-signaling pathways, and either mutations or overexpression of this gene have been observed in some cancers.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

RTAAACA_FREAC2_01 ,  FREAC7_01 ,  FOX_Q2 ,  P53_DECAMER_Q2 ,  NFAT_Q6 ,  E4BP4_01 ,  GCANCTGNY_MYOD_Q6 ,  HP1SITEFACTOR_Q6 ,  HNF1_C ,  PBX1_01 ,  TTAYRTAA_E4BP4_01 ,  LEF1_Q6 ,  CAGGTA_AREB6_01 ,  P53_02 ,  FOXJ2_01 ,  CREBP1_01 ,  S8_01 ,  FOXO1_01 ,  SOX5_01 ,  GFI1_01 ,  HLF_01 ,  TTGTTT_FOXO4_01 ,  AP4_Q6_01 ,  IK1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  SRY_02 ,  AP4_Q5 ,  ACAWYAAAG_UNKNOWN ,  HNF6_Q6

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Cytogenetic Map:

8q13.2

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