QuickView for PRICKLE1;jsessionid=415ABE3A4A81AE887F5BA7C420362841 (gene)

Gene Symbol:

PRICKLE1 Homo sapiens

Full name:

prickle planar cell polarity protein 1

Synonyms:

EPM1B, RILP, prickle-like protein 1, REST (RE-1 silencing transcription factor)/NRSF (neuron-restrictive silencer factor)-interacting LIM domain protein, REST/NRSF interacting LIM domain protein, REST/NRSF-interacting LIM domain protein 1, prickle homolog 1, prickle-like 1

Genomic Location:

Chr 12: 41139341-41269745

Description:

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alte...

View Full Description

This gene encodes a nuclear receptor that may be a negative regulator of the Wnt/beta-catenin signaling pathway. The encoded protein localizes to the nuclear membrane and has been implicated in the nuclear trafficking of the transcription repressors REST/NRSF and REST4. Mutations in this gene have been linked to progressive myoclonus epilepsy. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 3.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Canis lupus familiaris ,  Danio rerio ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

HNF1_01 ,  MYOD_01 ,  TTANTCA_UNKNOWN ,  HEN1_01 ,  E4BP4_01 ,  GCANCTGNY_MYOD_Q6 ,  CIZ_01 ,  ATF4_Q2 ,  YATTNATC_UNKNOWN ,  HP1SITEFACTOR_Q6 ,  LYF1_01 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  MYB_Q5_01 ,  RFX1_01 ,  TTAYRTAA_E4BP4_01 ,  CREB_Q3 ,  AML1_01 ,  CTTTGTA_MIR524 ,  STAT_Q6 ,  RP58_01 ,  AP4_Q6 ,  AP4_01 ,  GGGCGGR_SP1_Q6 ,  KCCGNSWTTT_UNKNOWN ,  MYB_Q6 ,  HMGIY_Q6 ,  HLF_01 ,  AML1_Q6 ,  HEN1_02 ,  RGAGGAARY_PU1_Q6 ,  TGACAGNY_MEIS1_01 ,  CAGCTG_AP4_Q5 ,  AACTTT_UNKNOWN ,  AP4_Q5 ,  HNF1_Q6 ,  CCTNTMAGA_UNKNOWN ,  MYB_Q3 ,  LBP1_Q6

View More

View Less

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-30 ,  Predicted Gene Targets for miR-384

Cytogenetic Map:

12q12

search → result