QuickView for PRIM2 (gene)
- Gene Symbol:
- PRIM2
Homo sapiens - Full name:
- DNA primase subunit 2
- Synonyms:
- PRIM2A, p58, DNA primase large subunit, DNA primase 58 kDa subunit, primase (DNA) subunit 2, primase, DNA, polypeptide 2 (58kDa)
- Genomic Location:
- Chr 6: 57290381-57621335
- Description:
-
This gene encodes the 58 kilodalton subunit of DNA primase, an enzyme that plays a key role in the replication of DNA. The encoded protein forms a heterodimer with a 49 kilodalton subunit. This heterodimer functions as a DNA-directed RNA polymerase to synthesize small RNA primers that are used to create Okazaki fragments on the lagging strand of th...
- Orthologs:
- Mus musculus , Rattus norvegicus , D. melanogaster , C. elegans , Saccharomyces cerevisiae , Macaca mulatta , Schizosaccharomyces pombe , Danio rerio , Gallus gallus , Canis lupus familiaris , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
6p11.2
GO Molecular Function
cofactor binding | cation binding | DNA primase activity | nucleic acid binding | 5'-3' RNA polymerase activity | single-stranded DNA binding | nucleotidyltransferase activity | catalytic activity | iron-sulfur cluster binding | DNA binding | ion binding | organic cyclic compound binding | transferase activity, transferring phosphorus-containing groups | transferase activity | 4 iron, 4 sulfur cluster binding | DNA-directed 5'-3' RNA polymerase activity | metal ion binding | heterocyclic compound binding
GO Biological Process
RNA metabolic process | telomere maintenance | cellular process | cellular homeostasis | DNA primase activity | cell cycle DNA replication | anatomical structure homeostasis | organic cyclic compound metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | DNA-dependent DNA replication | cellular component organization | cellular nitrogen compound biosynthetic process | cellular nitrogen compound metabolic process | telomere organization | cell cycle G1/S phase transition | cellular biosynthetic process | nitrogen compound metabolic process | DNA biosynthetic process | cell cycle | telomere maintenance via semi-conservative replication | biosynthetic process | aromatic compound biosynthetic process | mitotic cell cycle phase transition | homeostatic process | G1/S transition of mitotic cell cycle | DNA metabolic process | mitotic cell cycle | metabolic process | nucleobase-containing compound metabolic process | organic substance metabolic process | cellular macromolecule biosynthetic process | nuclear DNA replication | organelle organization | cell cycle phase transition | heterocycle metabolic process | DNA-directed 5'-3' RNA polymerase activity | chromosome organization | cellular metabolic process | DNA replication | DNA replication, synthesis of RNA primer | macromolecule metabolic process
GO Cellular Component
alpha DNA polymerase:primase complex | nuclear replisome | chromosome | intracellular membrane-bounded organelle | catalytic complex | nuclear replication fork | cell | nuclear lumen | replication fork | intracellular organelle | protein-containing complex | protein-DNA complex | nucleoplasm | nuclear chromosome | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | replisome | RNA polymerase complex | membrane-enclosed lumen | intracellular
