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QuickView for PRKCA;jsessionid=AAD1441EAA72ED8B68E6A198F5675623 (gene)


Gene Symbol:
PRKCA Homo sapiens Homo sapiens
Full name:
protein kinase C alpha
Synonyms:
AAG6, PKC-alpha, PKCA, PRKACA, protein kinase C alpha type, PKC-A, aging-associated gene 6
Genomic Location:
Chr 17: 61729388-62237324
Description:
Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for ph...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Danio rerio Bos taurus Gallus gallus Pan troglodytes Canis lupus familiaris
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 17
17q24.2





GO Molecular Function

histone threonine kinase activity | calcium-dependent protein kinase activity | cation binding | enzyme binding | protein-containing complex binding | ribonucleotide binding | nucleotide binding | signaling receptor binding | carbohydrate derivative binding | protein serine/threonine kinase activity | protein kinase C activity | catalytic activity | ATP binding | anion binding | adenyl nucleotide binding | calcium-dependent protein serine/threonine kinase activity | purine nucleotide binding | calcium-dependent protein kinase C activity | ion binding | integrin binding | organic cyclic compound binding | cell adhesion molecule binding | purine ribonucleoside triphosphate binding | protein binding | zinc ion binding | histone kinase activity | transferase activity, transferring phosphorus-containing groups | phosphotransferase activity, alcohol group as acceptor | protein kinase activity | transferase activity | transition metal ion binding | purine ribonucleotide binding | adenyl ribonucleotide binding | drug binding | kinase activity | histone kinase activity (H3-T6 specific) | metal ion binding | heterocyclic compound binding | small molecule binding

GO Biological Process

regulation of ERK1 and ERK2 cascade | cell morphogenesis | nucleus organization | regulation of muscle system process | positive regulation of locomotion | histone threonine kinase activity | response to cytokine | response to interleukin-1 | neuron projection morphogenesis | intracellular signal transduction | regulation of localization | regulation of programmed cell death | peptidyl-amino acid modification | regulation of immune system process | negative regulation of cellular process | positive regulation of developmental process | histone modification | cell differentiation | positive regulation of epithelial cell proliferation | nervous system development | cell part morphogenesis | neurogenesis | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of endothelial cell proliferation | positive regulation of cellular component movement | regulation of peptide hormone secretion | calcium-dependent protein kinase activity | generation of neurons | membrane organization | blood vessel morphogenesis | regulation of bone remodeling | cellular process | regulation of cell motility | cell projection morphogenesis | chromatin organization | neuron development | regulation of platelet aggregation | hemostasis | negative regulation of apoptotic process | endomembrane system organization | axon guidance | regulation of cell cycle | membrane disassembly | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | regulation of myeloid leukocyte differentiation | regulation of cell differentiation | positive regulation of cardiac muscle hypertrophy | cell junction assembly | regulation of platelet activation | regulation of mRNA stability | regulation of angiogenesis | regulation of cellular process | regulation of apoptotic process | regulation of metabolic process | positive regulation of cellular protein metabolic process | cellular component organization | positive regulation of epithelial cell migration | regulation of peptide secretion | regulation of vasculature development | response to stimulus | peptidyl-threonine phosphorylation | vasculature development | cell morphogenesis involved in neuron differentiation | positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway | regulation of insulin secretion | positive regulation of immune system process | positive regulation of protein metabolic process | response to stress | neuron projection guidance | posttranscriptional regulation of gene expression | regulation of cell proliferation | tube morphogenesis | mitotic nuclear envelope disassembly | protein serine/threonine kinase activity | programmed cell death | protein kinase C activity | cardiovascular system development | nuclear envelope organization | positive regulation of blood vessel endothelial cell migration | ERBB signaling pathway | regulation of protein transport | cellular component assembly | regulation of wound healing | protein modification process | regulation of peptide transport | regulation of cell adhesion | macromolecule modification | ERBB2 signaling pathway | blood vessel development | positive regulation of macrophage differentiation | blood coagulation | locomotion | apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | multicellular organism development | regulation of MAPK cascade | phosphorus metabolic process | regulation of phosphorylation | regulation of hormone levels | regulation of hormone secretion | wound healing | positive regulation of cell cycle | positive regulation of mitotic cell cycle | regulation of gene expression | platelet activation | axon development | cell cycle | positive regulation of dense core granule biogenesis | desmosome assembly | positive regulation of cellular metabolic process | positive regulation of protein phosphorylation | regulation of blood coagulation | calcium-dependent protein serine/threonine kinase activity | regulation of nitrogen compound metabolic process | regulation of cell migration | enzyme linked receptor protein signaling pathway | positive regulation of intracellular signal transduction | regulation of RNA stability | regulation of cellular component movement | axonogenesis | positive regulation of cell differentiation | regulation of endothelial cell migration | positive regulation of myeloid cell differentiation | positive regulation of cell migration | calcium-dependent protein kinase C activity | regulation of cellular protein metabolic process | histone H3-T6 phosphorylation | angiogenesis | phosphorylation | protein phosphorylation | cell morphogenesis involved in differentiation | phosphate-containing compound metabolic process | nuclear envelope disassembly | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | positive regulation of signal transduction | regulation of cAMP-mediated signaling | desmosome organization | positive regulation of cell proliferation | regulation of protein phosphorylation | regulation of locomotion | regulation of RNA metabolic process | histone phosphorylation | coagulation | apoptotic signaling pathway | regulation of mitotic cell cycle | neuron differentiation | protein metabolic process | regulation of cardiac muscle hypertrophy | regulation of establishment of protein localization | positive regulation of protein modification process | response to organic substance | regulation of homotypic cell-cell adhesion | regulation of hemopoiesis | histone kinase activity | response to wounding | regulation of lipopolysaccharide-mediated signaling pathway | regulation of intracellular signal transduction | anatomical structure development | mitotic cell cycle | cell surface receptor signaling pathway | cell projection organization | metabolic process | cell-cell junction assembly | regulation of body fluid levels | negative regulation of programmed cell death | positive regulation of lipopolysaccharide-mediated signaling pathway | regulation of bone resorption | regulation of tissue remodeling | regulation of secretion | cell adhesion | protein kinase activity | neuron projection development | positive regulation of cellular component biogenesis | organic substance metabolic process | cell death | regulation of mRNA catabolic process | regulation of endothelial cell proliferation | regulation of cell activation | regulation of protein secretion | positive regulation of G-protein coupled receptor protein signaling pathway | positive regulation of ERK1 and ERK2 cascade | positive regulation of cAMP-mediated signaling | regulation of phosphate metabolic process | positive regulation of endothelial cell migration | negative regulation of glial cell apoptotic process | cell activation | positive regulation of MAPK cascade | anatomical structure formation involved in morphogenesis | regulation of epithelial cell migration | regulation of response to wounding | regulation of cell communication | regulation of blood vessel endothelial cell migration | regulation of macrophage differentiation | signaling | covalent chromatin modification | cell development | regulation of epithelial cell proliferation | positive regulation of phosphorylation | cellular protein metabolic process | anatomical structure morphogenesis | positive regulation of tissue remodeling | regulation of developmental process | regulation of G-protein coupled receptor protein signaling pathway | kinase activity | developmental process | organelle organization | peptidyl-serine phosphorylation | cellular protein modification process | histone kinase activity (H3-T6 specific) | tube development | regulation of transport | regulation of cell-cell adhesion | positive regulation of bone resorption | transmembrane receptor protein tyrosine kinase signaling pathway | positive regulation of metabolic process | chromosome organization | positive regulation of myeloid leukocyte differentiation | cellular metabolic process | regulation of protein localization | regulation of cell death | positive regulation of cell motility | negative regulation of cell death | circulatory system development | chemotaxis | positive regulation of angiogenesis | positive regulation of signaling | signal transduction | regulation of signaling | macromolecule metabolic process | multicellular organismal process | cell-cell junction organization | regulation of phosphorus metabolic process

GO Cellular Component

intracellular membrane-bounded organelle | organelle membrane | cell | nuclear lumen | plasma membrane protein complex | cytoplasm | intracellular organelle | endoplasmic reticulum | protein-containing complex | endomembrane system | nucleoplasm | plasma membrane | vesicle | perinuclear region of cytoplasm | extracellular exosome | mitochondrion | extracellular region | membrane-bounded organelle | extracellular vesicle | nucleus | organelle | alphav-beta3 integrin-PKCalpha complex | mitochondrial envelope | extracellular space | cell periphery | membrane-enclosed lumen | mitochondrial membrane | cytosol | intracellular | membrane