QuickView for PRKN;jsessionid=E2446DA4AFDD77F5B653F3D9A5F279ED (gene)

GO Molecular Function

sequence-specific DNA binding | beta-catenin binding | actin binding | kinase binding | transcription regulatory region DNA binding | cation binding | protein kinase binding | enzyme binding | nucleic acid binding | SH3 domain binding | signaling receptor binding | ubiquitin-specific protease binding | ubiquitin binding | catalytic activity | chaperone binding | protein domain specific binding | Hsp70 protein binding | ubiquitin-like protein ligase binding | ubiquitin-like protein transferase activity | cytoskeletal protein binding | F-box domain binding | ubiquitin conjugating enzyme binding | DNA binding | sequence-specific double-stranded DNA binding | identical protein binding | ubiquitin protein ligase activity | ubiquitin-like protein binding | ion binding | organic cyclic compound binding | transcription regulatory region sequence-specific DNA binding | protein binding | zinc ion binding | double-stranded DNA binding | DNA-binding transcription factor activity | ubiquitin protein ligase binding | cullin family protein binding | ubiquitin-protein transferase activity | G-protein coupled receptor binding | ubiquitin-like protein conjugating enzyme binding | transferase activity | transition metal ion binding | ubiquitin-like protein ligase activity | PDZ domain binding | tubulin binding | phospholipase binding | protease binding | heat shock protein binding | histone deacetylase binding | metal ion binding | heterocyclic compound binding

GO Biological Process

protein modification by small protein removal | RNA metabolic process | negative regulation of JNK cascade | negative regulation of phosphorylation | regulation of supramolecular fiber organization | positive regulation of macromolecule biosynthetic process | regulation of intracellular protein transport | negative regulation of MAPK cascade | response to endoplasmic reticulum stress | regulation of cellular response to oxidative stress | positive regulation of cellular component organization | regulation of response to oxidative stress | regulation of cell morphogenesis | regulation of neurogenesis | regulation of cellular localization | negative regulation of peptide secretion | dopamine uptake involved in synaptic transmission | proteolysis | regulation of cell development | protein stabilization | protein localization to mitochondrion | regulation of localization | catechol-containing compound metabolic process | macroautophagy | regulation of carbohydrate metabolic process | regulation of programmed cell death | negative regulation of cellular response to oxidative stress | regulation of mitochondrial fission | establishment of localization | regulation of autophagy | response to dopamine | neuron cellular homeostasis | negative regulation of neuron death | selective autophagy | negative regulation of cellular process | negative regulation of kinase activity | positive regulation of developmental process | negative regulation of RNA biosynthetic process | response to metal ion | regulation of protein localization to membrane | cell differentiation | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | negative regulation of actin filament bundle assembly | nervous system development | negative regulation of mitochondrion organization | negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway | positive regulation of protein catabolic process | response to drug | negative regulation of protein phosphorylation | neurogenesis | regulation of spontaneous synaptic transmission | negative regulation of protein secretion | regulation of organelle organization | regulation of peptide hormone secretion | generation of neurons | negative regulation of hexokinase activity | dopamine transport | regulation of lipid transport | phenol-containing compound metabolic process | autophagy of mitochondrion | interaction with symbiont | regulation of neuron death | negative regulation of stress-activated protein kinase signaling cascade | positive regulation of cellular biosynthetic process | cellular process | protein K63-linked ubiquitination | regulation of catecholamine secretion | organic substance catabolic process | negative regulation of oxidative stress-induced neuron death | localization | cellular homeostasis | protein K27-linked ubiquitination | proteolysis involved in cellular protein catabolic process | regulation of mitochondrial membrane potential | negative regulation of signaling | chemical synaptic transmission | parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization | negative regulation of viral life cycle | negative regulation of nucleic acid-templated transcription | learning | macromolecule localization | negative regulation of response to endoplasmic reticulum stress | regulation of response to cytokine stimulus | negative regulation of apoptotic process | negative regulation of secretion | positive regulation of tumor necrosis factor-mediated signaling pathway | regulation of proteolysis | negative regulation of release of cytochrome c from mitochondria | positive regulation of nitrogen compound metabolic process | regulation of neuron projection development | negative regulation of hormone secretion | response to inorganic substance | regulation of canonical Wnt signaling pathway | establishment of localization in cell | negative regulation of establishment of protein localization | negative regulation of cellular metabolic process | regulation of binding | regulation of cell differentiation | interspecies interaction between organisms | negative regulation of neurotransmitter transport | anatomical structure homeostasis | negative regulation of apoptotic signaling pathway | regulation of cellular process | positive regulation of cell growth | regulation of apoptotic process | regulation of metabolic process | catabolic process | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | negative regulation of oxidative stress-induced cell death | cellular response to unfolded protein | cellular response to organonitrogen compound | response to topologically incorrect protein | cellular aromatic compound metabolic process | cellular component organization | protein deubiquitination | regulation of mitochondrial fusion | cellular response to topologically incorrect protein | cellular response to metal ion | positive regulation of protein binding | negative regulation of glucokinase activity | positive regulation of autophagy of mitochondrion | positive regulation of cellular protein catabolic process | regulation of peptide secretion | response to stimulus | lysosomal transport | negative regulation of protein transport | regulation of cellular protein localization | modulation by virus of host process | regulation of insulin secretion | positive regulation of protein metabolic process | regulation of cellular protein catabolic process | negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | response to stress | regulation of response to endoplasmic reticulum stress | positive regulation of cellular protein localization | vacuolar transport | cellular nitrogen compound biosynthetic process | regulation of response to drug | positive regulation of protein polyubiquitination | regulation of protein ubiquitination | protein destabilization | regulation of dendrite extension | positive regulation of proteolysis involved in cellular protein catabolic process | cellular response to inorganic substance | cellular protein catabolic process | cellular localization | organic hydroxy compound transport | regulation of neurotransmitter uptake | positive regulation of proteolysis | cellular nitrogen compound metabolic process | cellular response to toxic substance | proteasomal protein catabolic process | regulation of dopamine metabolic process | positive regulation of mitophagy in response to mitochondrial depolarization | negative regulation of viral genome replication | regulation of macroautophagy | negative regulation of transport | regulation of DNA binding | cellular response to organic cyclic compound | regulation of protein transport | dopamine uptake | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | protein modification process | mitochondrion to lysosome transport | regulation of peptide transport | modulation of chemical synaptic transmission | negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | cellular biosynthetic process | mitochondrion organization | macromolecule modification | cell-cell signaling | synaptic transmission, dopaminergic | protein K6-linked ubiquitination | dopamine metabolic process | regulation of intracellular transport | negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator | metal ion homeostasis | positive regulation of mitochondrion organization | regulation of catecholamine metabolic process | regulation of nucleic acid-templated transcription | regulation of membrane potential | regulation of cellular response to stress | regulation of neurotransmitter levels | organic hydroxy compound metabolic process | positive regulation of response to cytokine stimulus | response to nitrogen compound | negative regulation of neuron apoptotic process | system development | nitrogen compound metabolic process | regulation of signal transduction | positive regulation of organelle organization | negative regulation of secretion by cell | protein monoubiquitination | regulation of protein stability | negative regulation of phosphate metabolic process | positive regulation of neuron projection development | zinc ion homeostasis | regulation of exosomal secretion | regulation of actin cytoskeleton organization | multicellular organism development | negative regulation of catalytic activity | regulation of MAPK cascade | regulation of actin filament organization | learning or memory | regulation of oxidative stress-induced intrinsic apoptotic signaling pathway | regulation of catalytic activity | regulation of phosphorylation | regulation of intrinsic apoptotic signaling pathway | regulation of hormone levels | regulation of hormone secretion | free ubiquitin chain polymerization | cellular response to ammonium ion | modulation by host of viral process | regulation of neuron differentiation | regulation of gene expression | organic substance transport | cellular response to stress | nervous system process | protein catabolic process | synaptic signaling | modification of morphology or physiology of other organism | regulation of signal transduction by p53 class mediator | positive regulation of cellular metabolic process | positive regulation of autophagy of mitochondrion in response to mitochondrial depolarization | adult locomotory behavior | response to manganese ion | response to ammonium ion | mitochondrial transport | regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | negative regulation of signal transduction by p53 class mediator | positive regulation of cell projection organization | protein polymerization | positive regulation of intracellular signal transduction | vesicle-mediated transport | regulation of transcription by RNA polymerase II | response to oxidative stress | ubiquitin protein ligase activity | protein localization to organelle | negative regulation of exosomal secretion | positive regulation of cell differentiation | synaptic transmission, glutamatergic | negative regulation of viral process | cognition | biosynthetic process | locomotory behavior | negative regulation of neurotransmitter secretion | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | positive regulation of proteasomal protein catabolic process | negative regulation of peptide hormone secretion | negative regulation by host of viral process | cellular protein-containing complex assembly | norepinephrine metabolic process | negative regulation of stress-activated MAPK cascade | startle response | regulation of synaptic vesicle transport | response to toxic substance | regulation of apoptotic signaling pathway | cation homeostasis | autophagy | cellular response to drug | regulation of mitochondrion organization | cell communication | regulation of cellular metabolic process | positive regulation of protein localization to membrane | regulation of neuron apoptotic process | response to catecholamine | regulation of tumor necrosis factor-mediated signaling pathway | negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway | regulation of protein metabolic process | positive regulation of signal transduction | homeostatic process | positive regulation of protein linear polyubiquitination | regulation of protein phosphorylation | regulation of cytokine-mediated signaling pathway | regulation of RNA metabolic process | positive regulation of transport | viral process | regulation of viral process | proteasome-mediated ubiquitin-dependent protein catabolic process | regulation of dopamine secretion | protein K29-linked ubiquitination | regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway | organelle disassembly | drug metabolic process | regulation of autophagy of mitochondrion | positive regulation of molecular function | regulation of proteasomal ubiquitin-dependent protein catabolic process | negative regulation of exocytosis | protein polyubiquitination | ERAD pathway | response to monoamine | protein-containing complex assembly | negative regulation of carbohydrate metabolic process | protein metabolic process | DNA-binding transcription factor activity | negative regulation of mitochondrial fusion | regulation of establishment of protein localization | positive regulation of protein modification process | regulation of growth | response to organic substance | protein ubiquitination | catecholamine metabolic process | regulation of kinase activity | import into cell | negative regulation of intralumenal vesicle formation | regulation of intracellular signal transduction | negative regulation of intracellular signal transduction | regulation of exocytosis | cellular macromolecule catabolic process | protein autoubiquitination | anatomical structure development | positive regulation of neurogenesis | regulation of glucose metabolic process | metabolic process | positive regulation of cell development | negative regulation of response to oxidative stress | neurotransmitter uptake | positive regulation of ubiquitin-dependent protein catabolic process | ubiquitin-protein transferase activity | regulation of protein catabolic process | regulation of protein targeting | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | negative regulation of programmed cell death | regulation of proteasomal protein catabolic process | negative regulation of cytoskeleton organization | cellular protein localization | regulation of vesicle-mediated transport | chemical homeostasis | regulation of secretion | behavior | nucleobase-containing compound metabolic process | organic substance metabolic process | positive regulation of neurotransmitter uptake | negative regulation of intrinsic apoptotic signaling pathway | negative regulation of biosynthetic process | negative regulation of gene expression | regulation of endosome organization | negative regulation of cellular protein metabolic process | gene expression | regulation of protein secretion | negative regulation by host of viral genome replication | ion homeostasis | protein modification by small protein conjugation or removal | regulation of Wnt signaling pathway | regulation of phosphate metabolic process | positive regulation of retrograde transport, endosome to Golgi | positive regulation of binding | positive regulation of autophagy | transcription, DNA-templated | positive regulation of macroautophagy | positive regulation of intracellular transport | regulation of JNK cascade | drug transport | ubiquitin-dependent protein catabolic process | adult behavior | negative regulation of protein metabolic process | organonitrogen compound catabolic process | positive regulation of cytokine-mediated signaling pathway | protein K11-linked ubiquitination | regulation of stress-activated MAPK cascade | regulation of cell communication | mitophagy | regulation of retrograde transport, endosome to Golgi | aggresome assembly | response to mitochondrial depolarisation | negative regulation of molecular function | negative regulation of signal transduction | positive regulation of developmental growth | negative regulation of insulin secretion | signaling | positive regulation of I-kappaB kinase/NF-kappaB signaling | positive regulation of growth | regulation of transcription, DNA-templated | regulation of oxidoreductase activity | regulation of protein binding | response to organic cyclic compound | neuromuscular process | ubiquitin recycling | positive regulation of DNA binding | regulation of developmental growth | positive regulation of mitochondrial fission | negative regulation of spontaneous neurotransmitter secretion | protein localization | cellular protein metabolic process | response to unfolded protein | cation transport | cellular macromolecule localization | cellular macromolecule biosynthetic process | regulation of actin filament bundle assembly | ammonium transport | regulation of nervous system development | regulation of developmental process | regulation of ion transport | regulation of intrinsic apoptotic signaling pathway by p53 class mediator | developmental process | negative regulation of canonical Wnt signaling pathway | organelle organization | positive regulation of mitophagy | regulation of cell growth | cellular protein modification process | monoamine transport | cellular response to manganese ion | negative regulation of transcription by RNA polymerase II | regulation of transport | positive regulation of transcription, DNA-templated | modulation by virus of host morphology or physiology | regulation of reactive oxygen species metabolic process | neurotransmitter transport | negative regulation of oxidoreductase activity | positive regulation of nucleic acid-templated transcription | response to organonitrogen compound | positive regulation of transcription by RNA polymerase II | negative regulation of supramolecular fiber organization | heterocycle metabolic process | positive regulation of dendrite extension | negative regulation of synaptic transmission | protein K48-linked ubiquitination | cellular response to dopamine | central nervous system development | positive regulation of metabolic process | regulation of actin filament-based process | negative regulation of Wnt signaling pathway | positive regulation of neuron differentiation | mitochondrial fission | ion transport | regulation of cell projection organization | transition metal ion homeostasis | cellular metabolic process | regulation of viral genome replication | negative regulation of primary amine oxidase activity | cellular response to organic substance | regulation of protein localization | regulation of cell death | modification-dependent protein catabolic process | regulation of viral life cycle | negative regulation of cell death | positive regulation of mitochondrial fusion | regulation of ubiquitin-dependent protein catabolic process | divalent inorganic cation homeostasis | positive regulation of protein ubiquitination | regulation of I-kappaB kinase/NF-kappaB signaling | regulation of cellular component organization | regulation of cytoskeleton organization | negative regulation of reactive oxygen species metabolic process | positive regulation of signaling | cellular response to catecholamine stimulus | regulation of signaling | positive regulation of gene expression | regulation of neurotransmitter secretion | macromolecule metabolic process | multicellular organismal process | regulation of protein targeting to mitochondrion | regulation of phosphorus metabolic process

GO Cellular Component

mitochondrion-derived vesicle | intracellular membrane-bounded organelle | synapse | catalytic complex | neuron projection | cytoplasmic vesicle | Lewy body | cell | nuclear lumen | cytoplasm | intracellular organelle | endoplasmic reticulum | ubiquitin ligase complex | nuclear body | presynapse | inclusion body | Golgi apparatus | protein-containing complex | cell projection | endomembrane system | nucleoplasm | LUBAC complex | nuclear speck | vesicle | transferase complex | perinuclear region of cytoplasm | mitochondrion | cullin-RING ubiquitin ligase complex | membrane-bounded organelle | aggresome | nucleus | organelle | membrane-enclosed lumen | SCF ubiquitin ligase complex | Parkin-FBXW7-Cul1 ubiquitin ligase complex | cytosol | intracellular vesicle | intracellular

PATHWAYS

REACTOME_IMMUNE_SYSTEM | PID_ALPHA_SYNUCLEIN_PATHWAY | REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION | REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION | REACTOME_ADAPTIVE_IMMUNE_SYSTEM

PROTEIN FAMILY

Ubiquitin domain | IBR domain | E3 ubiquitin-protein ligase parkin | Ubiquitin-like domain superfamily | E3 ubiquitin ligase RBR family