QuickView for PRLR (gene)

Gene Symbol:

PRLR Homo sapiens

Full name:

prolactin receptor

Synonyms:

HPRL, MFAB, hPRLrI, prolactin receptor, hPRL receptor, secreted prolactin binding protein

Genomic Location:

Chr 5: 35099985-35266334

Description:

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have bee...

View Full Description

This gene encodes a receptor for the anterior pituitary hormone, prolactin, and belongs to the type I cytokine receptor family. Prolactin-dependent signaling occurs as the result of ligand-induced dimerization of the prolactin receptor. Several alternatively spliced transcript variants encoding different membrane-bound and soluble isoforms have been described for this gene, which may function to modulate the endocrine and autocrine effects of prolactin in normal tissue and cancer.

View Less

Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

DR3_Q4 ,  TGTTTAC_MIR30A5P_MIR30C_MIR30D_MIR30B_MIR30E5P ,  TGACCTY_ERR1_Q2 ,  CEBPB_02 ,  ACACTAC_MIR1423P ,  AAGCACA_MIR218

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-1 ,  Predicted Gene Targets for miR-142-3p ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-30

Cytogenetic Map:

5p13.2

search → result