QuickView for PRRX1 (gene)

Gene Symbol:

PRRX1 Homo sapiens

Full name:

paired related homeobox 1

Synonyms:

AGOTC, PHOX1, PMX1, PRX-1, PRX1, paired mesoderm homeobox protein 1, homeobox protein PHOX1, paired mesoderm homeobox 1 isoform pmx-1b

Genomic Location:

Chr 1: 168899937-168975165

Description:

The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates...

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The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription co-activator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Gallus gallus ,  Bos taurus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  PR_Q2 ,  OCT1_05 ,  PR_02 ,  OCT1_B ,  TTANTCA_UNKNOWN ,  MZF1_01 ,  P53_DECAMER_Q2 ,  AAAGGGA_MIR204_MIR211 ,  EFC_Q6 ,  HOXA4_Q2 ,  GATA3_01 ,  YATGNWAAT_OCT_C ,  OCT_Q6 ,  POU3F2_01 ,  YTATTTTNR_MEF2_02 ,  GAGACTG_MIR452 ,  AGCACTT_MIR93_MIR302A_MIR302B_MIR302C_MIR302D_MIR372_MIR373_MIR520E_MIR520A_MIR526B_MIR520B_MIR520C_MIR520D ,  GGGACCA_MIR133A_MIR133B ,  CIZ_01 ,  XBP1_01 ,  SRY_01 ,  CAGCACT_MIR5123P ,  AMEF2_Q6 ,  CTTTGA_LEF1_Q2 ,  CTAWWWATA_RSRFC4_Q2 ,  RFX1_01 ,  OCT1_Q5_01 ,  OCT_C ,  TCF4_Q5 ,  CTTTGTA_MIR524 ,  OSF2_Q6 ,  TFIII_Q6 ,  OCT1_Q6 ,  LEF1_Q6 ,  LEF1_Q2 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  LFA1_Q6 ,  P53_02 ,  CTACCTC_LET7A_LET7B_LET7C_LET7D_LET7E_LET7F_MIR98_LET7G_LET7I ,  PXR_Q2 ,  GR_Q6 ,  LHX3_01 ,  TGCCTTA_MIR124A ,  GCACTTT_MIR175P_MIR20A_MIR106A_MIR106B_MIR20B_MIR519D ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  GTGCCAA_MIR96 ,  GATA6_01 ,  CCCNNGGGAR_OLF1_01 ,  S8_01 ,  NKX61_01 ,  NKX25_02 ,  ACTGAAA_MIR30A3P_MIR30E3P ,  CTTTAAR_UNKNOWN ,  SPZ1_01 ,  GGCNNMSMYNTTG_UNKNOWN ,  OCT1_06 ,  RNGTGGGC_UNKNOWN ,  GTGCCTT_MIR506 ,  TTGCCAA_MIR182 ,  CHX10_01 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  GR_01 ,  CART1_01 ,  AFP1_Q6 ,  MEF2_03 ,  IK3_01 ,  YTAATTAA_LHX3_01 ,  PAX_Q6 ,  GTGGGTGK_UNKNOWN ,  GRE_C ,  CTTTGT_LEF1_Q2 ,  YWATTWNNRGCT_UNKNOWN ,  MMEF2_Q6 ,  CACBINDINGPROTEIN_Q6 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  ACCTGTTG_UNKNOWN ,  GTTAAAG_MIR302B ,  CACTTTG_MIR520G_MIR520H ,  HTF_01 ,  GGGTGGRR_PAX4_03 ,  HOX13_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for let-7 ,  Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-20 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-370 ,  Predicted Gene Targets for miR-9 ,  Predicted Gene Targets for miR-93 ,  Predicted Gene Targets for miR-124a ,  Predicted Gene Targets for miR-124u ,  Predicted Gene Targets for miR-410 ,  Predicted Gene Targets for miR-496

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Cytogenetic Map:

1q24.2

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