QuickView for PRSS2 (gene)

Gene Symbol:

PRSS2 Homo sapiens

Full name:

protease, serine 2

Synonyms:

TRY2, TRY8, TRYP2, trypsin-2, anionic trypsinogen, protease serine 2 preproprotein, protease, serine, 2 (trypsin 2), trypsin II, trypsinogen 2

Genomic Location:

Chr 7: 142178778-142182363

Description:

This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregu...

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This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TATAAA_TATA_01 ,  CAGGTG_E12_Q6 ,  TGTTTGY_HNF3_Q6

Cytogenetic Map:

7q34

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