QuickView for PSMA5;jsessionid=AA78685E94ABA4F1E15883E6C43F0140 (gene)

Gene Symbol:

PSMA5 Homo sapiens

Full name:

proteasome subunit alpha 5

Synonyms:

PSC5, ZETA, proteasome subunit alpha type-5, epididymis tissue sperm binding protein Li 11n, macropain subunit zeta, macropain zeta chain, multicatalytic endopeptidase complex zeta chain, proteasome (prosome, macropain) subunit, alpha type, 5, proteasome alpha 5 subunit, proteasome component 5, proteasome subunit zeta, proteasome zeta chain

Genomic Location:

Chr 1: 109745995-109770560

Description:

The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and ...

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The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Danio rerio ,  Gallus gallus ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGANTCA_AP1_C ,  WGTTNNNNNAAA_UNKNOWN ,  GGGCGGR_SP1_Q6 ,  AHR_Q5 ,  IRF_Q6 ,  ELK1_01 ,  SCGGAAGY_ELK1_02 ,  CTTTGT_LEF1_Q2 ,  ISRE_01 ,  STTTCRNTTT_IRF_Q6 ,  CP2_01 ,  TCF11MAFG_01

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Cytogenetic Map:

1p13.3

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