QuickView for PTAFR (gene)
- Gene Symbol:
- PTAFR
Homo sapiens - Full name:
- platelet activating factor receptor
- Synonyms:
- PAFR, platelet-activating factor receptor, PAF-R
- Genomic Location:
- Chr 1: 28348425-28375778
- Description:
-
This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and p...
- Orthologs:
- Mus musculus , Rattus norvegicus , Macaca mulatta , Danio rerio , Gallus gallus , Pan troglodytes , Canis lupus familiaris , Bos taurus
- External Links:
- Entrez Gene
- Transcription Factor
Binding Sites:
- Cytogenetic Map:
-
1p35.3
GO Molecular Function
kinase binding | protein kinase binding | transmembrane signaling receptor activity | enzyme binding | mitogen-activated protein kinase binding | lipid binding | G-protein coupled purinergic nucleotide receptor activity | G-protein coupled receptor activity | carbohydrate derivative binding | phospholipid binding | anion binding | signaling receptor activity | ion binding | platelet activating factor receptor activity | signaling pattern recognition receptor activity | protein binding | lipopolysaccharide receptor activity | lipopolysaccharide binding | purinergic nucleotide receptor activity
GO Biological Process
positive regulation of immune response | positive regulation of smooth muscle cell proliferation | regulation of blood vessel diameter | regulation of muscle system process | positive regulation of macromolecule biosynthetic process | positive regulation of locomotion | positive regulation of leukocyte adhesion to vascular endothelial cell | positive regulation of blood circulation | inositol trisphosphate biosynthetic process | exocytosis | response to cytokine | positive regulation of leukocyte tethering or rolling | positive regulation of ion transmembrane transporter activity | immune response-regulating signaling pathway | neutrophil activation | response to lipopolysaccharide | intracellular signal transduction | regulation of localization | regulation of carbohydrate metabolic process | establishment of localization | regulation of immune system process | response to hormone | positive regulation of maternal process involved in parturition | response to dexamethasone | purinergic nucleotide receptor signaling pathway | defense response | regulation of smooth muscle contraction | response to drug | regulation of inositol phosphate biosynthetic process | polyol metabolic process | positive regulation of cell adhesion | positive regulation of phosphate metabolic process | positive regulation of cellular component movement | positive regulation of sensory perception of pain | regulation of neutrophil degranulation | response to organophosphorus | innate immune response-activating signal transduction | positive regulation of neurological system process | positive regulation of cellular biosynthetic process | cellular process | response to symbiotic bacterium | secretion | leukocyte degranulation | regulation of cytokine biosynthetic process | regulation of cell motility | localization | cellular response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine | positive regulation of immune effector process | positive regulation of catalytic activity | positive regulation of nitrogen compound metabolic process | regulation of neurological system process | positive regulation of vasoconstriction | regulation of immune response | regulation of cellular process | leukocyte activation | parturition | cellular response to lipid | regulation of metabolic process | interferon-gamma-mediated signaling pathway | cellular response to molecule of bacterial origin | regulation of cellular extravasation | positive regulation of translation | positive regulation of cellular protein metabolic process | cellular response to organonitrogen compound | response to gravity | G-protein coupled purinergic nucleotide receptor activity | cellular response to interferon-gamma | positive regulation of tumor necrosis factor production | G-protein coupled receptor activity | response to stimulus | neutrophil degranulation | regulation of chloride transport | positive regulation of innate immune response | positive regulation of immune system process | positive regulation of protein metabolic process | regulation of blood vessel size | response to stress | leukocyte activation involved in immune response | posttranscriptional regulation of gene expression | alcohol metabolic process | regulation of cell proliferation | regulation of blood circulation | response to 2-O-acetyl-1-O-hexadecyl-sn-glycero-3-phosphocholine | positive regulation of cell-cell adhesion | phosphatidylinositol-mediated signaling | positive regulation of cytokine biosynthetic process | positive regulation of cell activation | activation of innate immune response | reproduction | secretion by cell | response to molecule of bacterial origin | G-protein coupled purinergic nucleotide receptor signaling pathway | positive regulation of lipase activity | immune response-activating signal transduction | cellular response to organic cyclic compound | blood circulation | G-protein coupled receptor signaling pathway | regulation of cell adhesion | negative regulation of blood pressure | regulation of nucleic acid-templated transcription | positive regulation of exocytosis | locomotion | organic hydroxy compound metabolic process | positive regulation of phospholipase C activity | response to nitrogen compound | response to external biotic stimulus | reproductive process | pattern recognition receptor signaling pathway | phosphorus metabolic process | response to purine-containing compound | response to fatty acid | leukocyte mediated immunity | regulation of muscle contraction | regulation of catalytic activity | regulation of sensory perception of pain | transcytosis | cellular response to ammonium ion | positive regulation of neutrophil degranulation | regulation of gene expression | positive regulation of secretion | response to ketone | response to lipid | regulation of blood pressure | organophosphate metabolic process | positive regulation of cellular metabolic process | regulation of anion channel activity | response to ammonium ion | positive regulation of ion transmembrane transport | regulation of nitrogen compound metabolic process | regulation of cell migration | small molecule metabolic process | regulation of interleukin-6 biosynthetic process | cytokine-mediated signaling pathway | response to corticosteroid | vesicle-mediated transport | regulation of cellular component movement | regulation of transcription by RNA polymerase II | positive regulation of hydrolase activity | positive regulation of cell migration | cellular response to cytokine stimulus | positive regulation of voltage-gated chloride channel activity | biosynthetic process | regulation of cellular protein metabolic process | regulated exocytosis | regulation of phospholipase activity | inositol lipid-mediated signaling | response to xenobiotic stimulus | regulation of tumor necrosis factor production | regulation of leukocyte migration | phosphate-containing compound metabolic process | positive regulation of cellular extravasation | positive regulation of regulated secretory pathway | cellular response to drug | response to bacterium | positive regulation of anion channel activity | cell communication | regulation of cellular metabolic process | positive regulation of smooth muscle contraction | platelet activating factor receptor activity | signaling pattern recognition receptor activity | positive regulation of transporter activity | inflammatory response | positive regulation of inositol phosphate biosynthetic process | cell activation involved in immune response | positive regulation of transcytosis | myeloid cell activation involved in immune response | regulation of protein metabolic process | neutrophil activation involved in immune response | positive regulation of cell proliferation | regulation of locomotion | regulation of RNA metabolic process | lipopolysaccharide-mediated signaling pathway | regulation of tube size | positive regulation of transport | cellular response to fatty acid | regulation of phospholipase C activity | positive regulation of molecular function | cytokine production | activation of immune response | response to organic substance | regulation of innate immune response | lipopolysaccharide receptor activity | inositol trisphosphate metabolic process | response to antineoplastic agent | regulation of exocytosis | cell surface receptor signaling pathway | regulation of vasoconstriction | metabolic process | regulation of RNA biosynthetic process | positive regulation of leukocyte activation | regulation of tube diameter | regulation of vesicle-mediated transport | regulation of secretion | positive regulation of interleukin-6 production | immune response | positive regulation of inorganic anion transmembrane transport | positive regulation of muscle contraction | organic substance metabolic process | positive regulation of ion transport | regulation of cell activation | positive regulation of leukocyte migration | cellular response to cAMP | regulation of phosphate metabolic process | regulation of ion transmembrane transport | response to interferon-gamma | positive regulation of cytokine production | regulation of regulated secretory pathway | positive regulation of phospholipase activity | response to cAMP | cell activation | positive regulation of carbohydrate metabolic process | cellular response to gravity | signaling | regulation of transcription, DNA-templated | response to organic cyclic compound | regulation of transmembrane transporter activity | regulation of ion transmembrane transporter activity | regulation of cytokine production | response to symbiont | response to biotic stimulus | positive regulation of gastro-intestinal system smooth muscle contraction | regulation of ion transport | positive regulation of anion transport | purinergic nucleotide receptor activity | regulation of transport | regulation of cell-cell adhesion | innate immune response | neutrophil mediated immunity | response to organonitrogen compound | positive regulation of interleukin-6 biosynthetic process | regulation of anion transport | positive regulation of metabolic process | immune system process | cellular metabolic process | cellular response to organic substance | regulation of smooth muscle cell proliferation | positive regulation of cell motility | response to steroid hormone | regulation of translation | regulation of interleukin-6 production | positive regulation of blood vessel diameter | chemotaxis | positive regulation of leukocyte cell-cell adhesion | inositol phosphate biosynthetic process | response to other organism | inositol phosphate metabolic process | signal transduction | positive regulation of gene expression | response to glucocorticoid | cellular response to lipopolysaccharide | multicellular organismal process | regulation of phosphorus metabolic process
GO Cellular Component
secretory granule | integral component of membrane | organelle membrane | tertiary granule | cytoplasmic vesicle | cell | intrinsic component of membrane | cytoplasm | intracellular organelle | secretory granule membrane | secretory vesicle | endomembrane system | plasma membrane | vesicle | integral component of plasma membrane | membrane-bounded organelle | organelle | vesicle membrane | cell periphery | tertiary granule membrane | intracellular vesicle | intracellular | membrane | cytoplasmic vesicle membrane | intrinsic component of plasma membrane
