QuickView for PTH1R (gene)

Gene Symbol:

PTH1R Homo sapiens

Full name:

parathyroid hormone 1 receptor

Synonyms:

PFE, PTHR, PTHR1, parathyroid hormone/parathyroid hormone-related peptide receptor, PTH/PTHr receptor, PTH/PTHrP type I receptor, PTH1 receptor, parathyroid hormone receptor 1, parathyroid hormone/parathyroid hormone-related protein receptor, seven transmembrane helix receptor

Genomic Location:

Chr 3: 46894240-46920293

Description:

The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. D...

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The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH) and for parathyroid hormone-like hormone (PTHLH). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. Defects in this receptor are known to be the cause of Jansen's metaphyseal chondrodysplasia (JMC), chondrodysplasia Blomstrand type (BOCD), as well as enchodromatosis. Two transcript variants encoding the same protein have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

POU6F1_01 ,  RTAAACA_FREAC2_01 ,  HNF4ALPHA_Q6 ,  AGCYRWTTC_UNKNOWN ,  TGANTCA_AP1_C ,  HNF1_01 ,  RYTTCCTG_ETS2_B ,  P53_DECAMER_Q2 ,  FOXO4_01 ,  NKX3A_01 ,  GCANCTGNY_MYOD_Q6 ,  MEIS1BHOXA9_01 ,  COUP_01 ,  HNF4_DR1_Q3 ,  GGGAGGRR_MAZ_Q6 ,  P53_02 ,  CDX2_Q5 ,  DR1_Q3 ,  LHX3_01 ,  NKX62_Q2 ,  CAGNWMCNNNGAC_UNKNOWN ,  NF1_Q6 ,  S8_01 ,  NF1_Q6_01 ,  TAATTA_CHX10_01 ,  WGGAATGY_TEF1_Q6 ,  AP4_Q6_01 ,  AAAYRNCTG_UNKNOWN ,  COUP_DR1_Q6 ,  CTTTGT_LEF1_Q2 ,  ER_Q6_01 ,  CAGCTG_AP4_Q5 ,  PPAR_DR1_Q2 ,  PAX2_02 ,  RYTAAWNNNTGAY_UNKNOWN ,  FREAC4_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133

Cytogenetic Map:

3p21.31

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