QuickView for PTPA (gene)

Gene Symbol:

PTPA Homo sapiens

Full name:

protein phosphatase 2 phosphatase activator

Synonyms:

PP2A, PPP2R4, PR53, serine/threonine-protein phosphatase 2A activator, PP2A phosphatase activator, PP2A subunit B' isoform PR53, phosphotyrosyl phosphatase activator, protein phosphatase 2 regulatory subunit 4, protein phosphatase 2A activator, regulatory subunit 4, protein phosphatase 2A regulatory subunit 4, protein phosphatase 2A, regulatory subunit B' (PR 53), serine/threonine-protein phosphatase 2A regulatory subunit B'

Genomic Location:

Chr 9: 130913065-130951044

Description:

Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes ...

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Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. Protein phosphatase 2A holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a regulatory subunit B. The regulatory subunit is encoded by a diverse set of genes that have been grouped into the B/PR55, B'/PR61, and B''/PR72 families. These different regulatory subunits confer distinct enzymatic specificities and intracellular localizations to the holozenzyme. The product of this gene belongs to the B' family. This gene encodes a specific phosphotyrosyl phosphatase activator of the dimeric form of protein phosphatase 2A. Alternative splicing results in multiple transcript variants encoding different isoforms.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  C. elegans ,  Saccharomyces cerevisiae ,  Macaca mulatta ,  Schizosaccharomyces pombe ,  Gallus gallus ,  Danio rerio ,  Pan troglodytes ,  Canis lupus familiaris ,  Bos taurus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CMYB_01 ,  AREB6_02 ,  YGTCCTTGR_UNKNOWN ,  E2A_Q2 ,  P53_02 ,  CAGGTG_E12_Q6 ,  MYOD_Q6 ,  AAAYRNCTG_UNKNOWN ,  TGACAGNY_MEIS1_01 ,  AAGCACA_MIR218

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-218

Cytogenetic Map:

9q34.11

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