QuickView for PTPRE (gene)

Gene Symbol:

PTPRE Homo sapiens

Full name:

protein tyrosine phosphatase, receptor type E

Synonyms:

HPTPE, PTPE, R-PTP-EPSILON, receptor-type tyrosine-protein phosphatase epsilon, protein tyrosine phosphatase, receptor type, epsilon polypeptide

Genomic Location:

Chr 10: 129595315-129774155

Description:

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, ...

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The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Several alternatively spliced transcript variants of this gene have been reported, at least two of which encode a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokine-induced SATA signaling, as well as the activation of voltage-gated K+ channels.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Gallus gallus ,  Pan troglodytes ,  Bos taurus ,  Danio rerio ,  Canis lupus familiaris

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GAGCCTG_MIR484 ,  ATCTTGC_MIR31 ,  CTTTGTA_MIR524 ,  TGCCTTA_MIR124A ,  ATGTTAA_MIR302C ,  TCTCTCC_MIR185 ,  RNGTGGGC_UNKNOWN ,  YRCCAKNNGNCGC_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-142-5p ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-192 ,  Predicted Gene Targets for miR-381 ,  Predicted Gene Targets for miR-495

Cytogenetic Map:

10q26.2

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