QuickView for PTX3 (gene)

Gene Symbol:

PTX3 Homo sapiens

Full name:

pentraxin 3

Synonyms:

TNFAIP5, TSG-14, pentraxin-related protein PTX3, TNF alpha-induced protein 5, long pentraxin 3, tumor necrosis factor alpha-induced protein 5, tumor necrosis factor-inducible gene 14 protein, tumor necrosis factor-inducible protein TSG-14

Genomic Location:

Chr 3: 158637301-158644071

Description:

This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating ...

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This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several inflammatory conditions.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Pan troglodytes ,  Bos taurus ,  Gallus gallus ,  Danio rerio

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

CTACTGT_MIR199A ,  GTGACTT_MIR224 ,  CEBP_Q2 ,  CTGCAGY_UNKNOWN

miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-101 ,  Predicted Gene Targets for miR-144 ,  Predicted Gene Targets for miR-224 ,  Predicted Gene Targets for miR-30-3p ,  Predicted Gene Targets for miR-326

Cytogenetic Map:

3q25.32

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