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QuickView for Paf1 (gene)


Gene Symbol:
PAF1 Homo sapiens Homo sapiens
Full name:
PAF1 homolog, Paf1/RNA polymerase II complex component
Synonyms:
F23149_1, PD2, RNA polymerase II-associated factor 1 homolog, Paf1, RNA polymerase II associated factor, homolog, pancreatic differentiation protein 2
Genomic Location:
Chr 19: 44568109-44573519
Description:
This gene encodes a subunit of the polymerase associated factor (PAF1) complex. The PAF1 complex interacts with RNA polymerase II and plays a role in transcription elongation as well as histone modifications including ubiquitylation and methylation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gen...
Orthologs:
Mus musculus Rattus norvegicus D. melanogaster C. elegans Macaca mulatta Pan troglodytes Canis lupus familiaris Bos taurus Danio rerio
External Links:
Entrez Gene
Transcription Factor
Binding Sites:
miRNA binding sites
(Source: TargetScan):
Cytogenetic Map:
chr 19
19q13.2





GO Molecular Function

RNA polymerase II complex binding | RNA polymerase binding | enzyme binding | chromatin binding | RNA polymerase core enzyme binding | protein binding | basal RNA polymerase II transcription machinery binding

GO Biological Process

RNA metabolic process | transcription by RNA polymerase II | regulation of cell cycle process | positive regulation of macromolecule biosynthetic process | negative regulation of immune system process | RNA processing | positive regulation of cellular component organization | response to lipopolysaccharide | regulation of cell cycle G1/S phase transition | nucleosome organization | regulation of immune system process | negative regulation of cellular process | negative regulation of RNA biosynthetic process | histone modification | cell differentiation | regulation of organelle organization | regulation of mRNA processing | positive regulation of cellular biosynthetic process | cellular process | localization | chromatin organization | negative regulation of nucleic acid-templated transcription | stem cell population maintenance | macromolecule localization | regulation of histone modification | regulation of cell cycle | regulation of myeloid cell differentiation | positive regulation of nitrogen compound metabolic process | negative regulation of cellular metabolic process | tissue development | regulation of cell differentiation | regulation of cellular process | cellular response to lipid | regulation of metabolic process | cellular response to molecule of bacterial origin | positive regulation of cell cycle phase transition | organic cyclic compound metabolic process | positive regulation of cellular protein metabolic process | RNA biosynthetic process | cellular aromatic compound metabolic process | cellular component organization | regulation of histone methylation | response to stimulus | positive regulation of protein metabolic process | cellular nitrogen compound biosynthetic process | protein localization to nucleus | regulation of cell cycle phase transition | cellular localization | response to molecule of bacterial origin | cellular nitrogen compound metabolic process | endodermal cell fate commitment | negative regulation of metabolic process | positive regulation of RNA biosynthetic process | cellular component assembly | positive regulation of mRNA processing | negative regulation of hemopoiesis | protein modification process | mRNA metabolic process | cellular biosynthetic process | embryo development | macromolecule modification | cell-cell signaling | mRNA polyadenylation | cell surface receptor signaling pathway involved in cell-cell signaling | regulation of nucleic acid-templated transcription | RNA polyadenylation | response to external biotic stimulus | nitrogen compound metabolic process | positive regulation of organelle organization | Wnt signaling pathway | protein monoubiquitination | multicellular organism development | positive regulation of chromosome organization | positive regulation of cell cycle | regulation of gene expression | response to lipid | positive regulation of cellular metabolic process | regulation of mRNA 3'-end processing | negative regulation of myeloid cell differentiation | regulation of nitrogen compound metabolic process | protein modification by small protein conjugation | regulation of transcription by RNA polymerase II | endoderm formation | protein localization to organelle | biosynthetic process | regulation of cellular protein metabolic process | aromatic compound biosynthetic process | regulation of transcription elongation from RNA polymerase II promoter | transcription elongation from RNA polymerase II promoter | positive regulation of cell cycle G1/S phase transition | response to bacterium | cell communication | regulation of cellular metabolic process | regulation of protein metabolic process | nucleosome positioning | regulation of RNA metabolic process | embryonic morphogenesis | protein metabolic process | positive regulation of protein modification process | response to organic substance | protein ubiquitination | regulation of hemopoiesis | chromatin assembly or disassembly | anatomical structure development | cell surface receptor signaling pathway | metabolic process | cell fate commitment | positive regulation of transcription elongation from RNA polymerase II promoter | RNA 3'-end processing | regulation of RNA biosynthetic process | negative regulation of transcription, DNA-templated | cellular protein localization | nucleobase-containing compound metabolic process | organic substance metabolic process | maintenance of cell number | negative regulation of biosynthetic process | negative regulation of gene expression | positive regulation of histone modification | gene expression | protein modification by small protein conjugation or removal | positive regulation of mRNA 3'-end processing | DNA packaging | regulation of chromosome organization | regulation of DNA-templated transcription, elongation | transcription, DNA-templated | chromatin assembly | anatomical structure formation involved in morphogenesis | histone ubiquitination | signaling | covalent chromatin modification | regulation of transcription, DNA-templated | protein localization | cellular protein metabolic process | endodermal cell differentiation | endoderm development | anatomical structure morphogenesis | cellular macromolecule localization | cellular macromolecule biosynthetic process | cell fate commitment involved in formation of primary germ layer | response to biotic stimulus | histone H2B ubiquitination | regulation of developmental process | developmental process | positive regulation of DNA-templated transcription, elongation | organelle organization | positive regulation of cell cycle process | cellular protein modification process | histone monoubiquitination | negative regulation of transcription by RNA polymerase II | positive regulation of transcription, DNA-templated | positive regulation of nucleic acid-templated transcription | DNA conformation change | formation of primary germ layer | positive regulation of transcription by RNA polymerase II | heterocycle metabolic process | positive regulation of metabolic process | chromosome organization | mRNA 3'-end processing | positive regulation of histone methylation | gastrulation | cellular metabolic process | mRNA processing | cellular response to organic substance | negative regulation of cell differentiation | regulation of cellular component organization | response to other organism | signal transduction | positive regulation of gene expression | cellular response to lipopolysaccharide | macromolecule metabolic process | multicellular organismal process | DNA-templated transcription, elongation | regulation of chromatin organization

GO Cellular Component

chromosome | intracellular membrane-bounded organelle | catalytic complex | transcription elongation factor complex | cell | nuclear lumen | cytoplasm | intracellular organelle | protein-containing complex | nucleoplasm | chromatin | transferase complex | membrane-bounded organelle | nucleus | organelle | nuclear DNA-directed RNA polymerase complex | RNA polymerase complex | membrane-enclosed lumen | transcriptionally active chromatin | intracellular | cell junction | Cdc73/Paf1 complex | membrane | RNA polymerase II, holoenzyme