QuickView for Pak4 (gene)

Gene Symbol:

PAK4 Homo sapiens

Full name:

p21 (RAC1) activated kinase 4

Synonyms:

serine/threonine-protein kinase PAK 4, p21 protein (Cdc42/Rac)-activated kinase 4, p21(CDKN1A)-activated kinase 4, protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs

Genomic Location:

Chr 19: 44308260-44361886

Description:

PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities...

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PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Gallus gallus

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

GATTGGY_NFY_Q6_01 ,  HNF4ALPHA_Q6 ,  PPARG_01 ,  ZIC1_01 ,  TGAATGT_MIR181A_MIR181B_MIR181C_MIR181D ,  STAT6_01 ,  CTTTGA_LEF1_Q2 ,  COUP_01 ,  HNF4_DR1_Q3 ,  HNF4_01 ,  ATCATGA_MIR433 ,  GGGYGTGNY_UNKNOWN ,  RFX1_02 ,  DR1_Q3 ,  SP1_Q4_01 ,  ACCAAAG_MIR9 ,  GGGCGGR_SP1_Q6 ,  STAT5A_03 ,  CTTTAAR_UNKNOWN ,  SP1_Q6 ,  CTGAGCC_MIR24 ,  COUP_DR1_Q6 ,  GGCCAGT_MIR193A_MIR193B ,  ACAWNRNSRCGG_UNKNOWN ,  CAGCCTC_MIR4855P ,  SP1_Q6_01 ,  PPAR_DR1_Q2 ,  HNF1_Q6 ,  HNF4_01_B ,  SP1_Q2_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-181 ,  Predicted Gene Targets for miR-193 ,  Predicted Gene Targets for miR-24 ,  Predicted Gene Targets for miR-433-3p ,  Predicted Gene Targets for miR-485-5p ,  Predicted Gene Targets for miR-9

Cytogenetic Map:

19q13.2

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