QuickView for Pax2 (gene)

Gene Symbol:

PAX2 Homo sapiens

Full name:

paired box 2

Synonyms:

FSGS7, PAPRS, paired box protein Pax-2, paired box homeotic gene 2

Genomic Location:

Chr 10: 102495458-102579688

Description:

PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to re...

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PAX2 encodes paired box gene 2, one of many human homologues of the Drosophila melanogaster gene prd. The central feature of this transcription factor gene family is the conserved DNA-binding paired box domain. PAX2 is believed to be a target of transcriptional supression by the tumor suppressor gene WT1. Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. Alternative splicing of this gene results in multiple transcript variants.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  D. melanogaster ,  Macaca mulatta ,  Gallus gallus ,  Danio rerio ,  Canis lupus familiaris ,  Bos taurus ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

PR_Q2 ,  IRF1_01 ,  NFMUE1_Q6 ,  CGGAARNGGCNG_UNKNOWN ,  PU1_Q6 ,  CTCTATG_MIR368 ,  TCANNTGAY_SREBP1_01 ,  OCT1_04 ,  HEN1_01 ,  GATA_Q6 ,  GATA_C ,  SMAD3_Q6 ,  CTTTGCA_MIR527 ,  CTATGCA_MIR153 ,  YATTNATC_UNKNOWN ,  GATAAGR_GATA_C ,  HNF1_C ,  GR_Q6_01 ,  E2A_Q2 ,  GGGCATT_MIR365 ,  CTCNANGTGNY_UNKNOWN ,  MYCMAX_B ,  WTGAAAT_UNKNOWN ,  GGGAGGRR_MAZ_Q6 ,  GGTGTGT_MIR329 ,  TFIII_Q6 ,  DBP_Q6 ,  PAX4_02 ,  GGATTA_PITX2_Q2 ,  TEF1_Q6 ,  CAGGTG_E12_Q6 ,  TNCATNTCCYR_UNKNOWN ,  GR_Q6 ,  EVI1_02 ,  TST1_01 ,  GCAAAAA_MIR129 ,  GGGCGGR_SP1_Q6 ,  TGCTGAY_UNKNOWN ,  LMO2COM_02 ,  CCCNNGGGAR_OLF1_01 ,  NKX25_02 ,  TGCCAAR_NF1_Q6 ,  SPZ1_01 ,  OCT1_06 ,  AHRARNT_01 ,  TCTCTCC_MIR185 ,  OCT1_02 ,  AP2_Q6 ,  TAATTA_CHX10_01 ,  TTGTTT_FOXO4_01 ,  MYOGENIN_Q6 ,  PIT1_Q6 ,  RTTTNNNYTGGM_UNKNOWN ,  WTTGKCTG_UNKNOWN ,  CP2_02 ,  SREBP_Q3 ,  CCCNNNNNNAAGWT_UNKNOWN ,  TGATTTRY_GFI1_01 ,  CGGTGTG_MIR220 ,  TGACAGNY_MEIS1_01 ,  CTTTGT_LEF1_Q2 ,  CAGCTG_AP4_Q5 ,  ISRE_01 ,  CDC5_01 ,  AACTTT_UNKNOWN ,  MZF1_02 ,  GGCKCATGS_UNKNOWN ,  HNF1_Q6 ,  SP1_Q2_01 ,  AAGCACA_MIR218 ,  TCF11_01

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-129 ,  Predicted Gene Targets for miR-139 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-185 ,  Predicted Gene Targets for miR-204 ,  Predicted Gene Targets for miR-218 ,  Predicted Gene Targets for miR-329 ,  Predicted Gene Targets for miR-342 ,  Predicted Gene Targets for miR-365 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-450 ,  Predicted Gene Targets for miR-375

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Cytogenetic Map:

10q24.31

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