QuickView for Pcdhgc3 (gene)

Gene Symbol:

PCDHGC3 Homo sapiens

Full name:

protocadherin gamma subfamily C, 3

Synonyms:

PC43, PCDH-GAMMA-C3, PCDH2, protocadherin gamma-C3, cadherin-like 2, protocadherin 43, protocadherin-2

Genomic Location:

Chr 5: 140835753-140872730

Description:

This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subf...

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This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.

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Orthologs:

Mus musculus ,  Rattus norvegicus ,  Macaca mulatta ,  Bos taurus ,  Gallus gallus ,  Canis lupus familiaris ,  Pan troglodytes

External Links:

Entrez Gene

Transcription Factor
Binding Sites:

TGGAAA_NFAT_Q4_01 ,  TGGNNNNNNKCCAR_UNKNOWN ,  SYATTGTG_UNKNOWN ,  GGGACCA_MIR133A_MIR133B ,  CEBP_Q2_01 ,  CTTTGA_LEF1_Q2 ,  IRF1_Q6 ,  TTF1_Q6 ,  WTGAAAT_UNKNOWN ,  CEBPB_01 ,  HNF4_Q6 ,  NF1_Q6 ,  TGCTGAY_UNKNOWN ,  IRF_Q6 ,  NF1_Q6_01 ,  PTF1BETA_Q6 ,  ATATGCA_MIR448 ,  AFP1_Q6 ,  MSX1_01 ,  WTTGKCTG_UNKNOWN ,  TGATTTRY_GFI1_01 ,  TGACAGNY_MEIS1_01 ,  ICSBP_Q6 ,  ISRE_01 ,  CDC5_01 ,  ZF5_B ,  AACTTT_UNKNOWN ,  CRX_Q4 ,  TCCAGAG_MIR518C

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miRNA binding sites
(Source: TargetScan):

Predicted Gene Targets for miR-133 ,  Predicted Gene Targets for miR-135 ,  Predicted Gene Targets for miR-153 ,  Predicted Gene Targets for miR-448 ,  Predicted Gene Targets for miR-7

Cytogenetic Map:

5q31.3

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