QuickView for Pglyrp4 (gene)
- Gene Symbol:
- PGLYRP4
Homo sapiens - Full name:
- peptidoglycan recognition protein 4
- Synonyms:
- PGLYRPIbeta, PGRP-Ibeta, PGRPIB, SBBI67, peptidoglycan recognition protein 4, PGRP-I-beta, peptidoglycan recognition protein I-beta, peptidoglycan recognition protein intermediate beta
- Genomic Location:
- Chr 1: 151569220-151587646
- Description:
-
Summary: This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. These proteins are part of the innate immune system and recognize peptidoglycan, a ubiquitous component of bacterial cell walls. This antimicrobial protein binds to murein peptidoglycans of Gram-positive bacteria.
- Orthologs:
- Mus musculus , Rattus norvegicus , Bos taurus , Pan troglodytes
- External Links:
- Entrez Gene
- Cytogenetic Map:
-
1q21.3
| Transcripts Names |
|---|
| NM_020393 |
| XM_011509791 |
| XM_011509790 |
| XM_011509792 |
| XM_011509793 |
| XM_011509789 |
| XR_921897 |
| XR_001737322 |
GO Molecular Function
N-acetylmuramoyl-L-alanine amidase activity | cation binding | hydrolase activity | carbohydrate derivative binding | catalytic activity | peptidoglycan receptor activity | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds | signaling receptor activity | protein heterodimerization activity | ion binding | signaling pattern recognition receptor activity | protein binding | peptidoglycan binding | zinc ion binding | protein dimerization activity | glycosaminoglycan binding | transition metal ion binding | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides | metal ion binding
GO Biological Process
positive regulation of immune response | negative regulation of lymphocyte differentiation | negative regulation of leukocyte activation | positive regulation of cell killing | negative regulation of immune system process | detection of stimulus | immune response-regulating signaling pathway | defense response to other organism | regulation of immune system process | negative regulation of cellular process | defense response | peptidoglycan catabolic process | innate immune response-activating signal transduction | cellular process | organic substance catabolic process | carbohydrate derivative catabolic process | positive regulation of killing of cells of other organism | glycosaminoglycan catabolic process | regulation of cytolysis | regulation of cell differentiation | interspecies interaction between organisms | regulation of immune response | regulation of cellular process | catabolic process | regulation of natural killer cell activation | response to stimulus | positive regulation of innate immune response | positive regulation of immune system process | response to stress | negative regulation of lymphocyte activation | negative regulation of interferon-gamma production | activation of innate immune response | immune response-activating signal transduction | negative regulation of hemopoiesis | regulation of lymphocyte differentiation | peptidoglycan receptor activity | response to external biotic stimulus | nitrogen compound metabolic process | pattern recognition receptor signaling pathway | regulation of killing of cells of other organism | cell killing | modification of morphology or physiology of other organism | negative regulation of cytokine production | regulation of lymphocyte activation | negative regulation of immune response | positive regulation of cytolysis | peptidoglycan metabolic process | response to bacterium | cell communication | negative regulation of natural killer cell differentiation involved in immune response | positive regulation of cytolysis in other organism | antimicrobial humoral immune response mediated by antimicrobial peptide | signaling pattern recognition receptor activity | negative regulation of cell activation | humoral immune response | defense response to bacterium | negative regulation of natural killer cell activation | antimicrobial humoral response | regulation of natural killer cell differentiation involved in immune response | activation of immune response | regulation of innate immune response | regulation of hemopoiesis | killing of cells of other organism | metabolic process | immune response | organic substance metabolic process | regulation of cell activation | detection of bacterium | organonitrogen compound catabolic process | regulation of natural killer cell differentiation | defense response to Gram-positive bacterium | signaling | regulation of cytokine production | response to biotic stimulus | regulation of developmental process | detection of biotic stimulus | carbohydrate derivative metabolic process | innate immune response | regulation of interferon-gamma production | immune system process | negative regulation of cell differentiation | response to other organism | signal transduction | glycosaminoglycan metabolic process | macromolecule metabolic process
GO Cellular Component
cell | protein-containing complex | extracellular region | extracellular space | intracellular | membrane
